A pediatric case series of invasive pneumococcal disease caused by S.Pneumonia serotype-19A despite full dose vaccination

Figures & data

Table 1. Clinical features of cases with invasive pneumococcal disease.

Characteristic	Case 1	Case 2	Case 3	Case 4
Age (years)	3	5	3,5	3
Sex	Girl	Boy	Girl	Girl
Sign(s) and symptom(s)	Fever, productive cough, shortness of breath	Fever, cough	fever, unconsciousness, otalgia	Fever, otalgia
Symptom duration before hospitalization (days)	4	5	5	4
Prior antibiotic use before sample collection	Amoxicilline clavulonate	Amoxicilline clavulonate	Amoxicilline clavulonate	None
Clinical presentation	Necrotizing pneumonia+ Empyema	Empyema	Bacterial meningitis + MODS	Acute otitis media + Bacterial meningitis
Vaccine History	PCV 13	PCV 13	PCV 13	PCV 13
Underlying Illness	None	Apert Syndrome	None	None
Antibiotic regimen	Ceftriaxone + Vancomycin	Ampicillin sulbactam	Ceftriaxone + Vancomycin	Ceftriaxone + Vancomycin
Sterile site of S. pneumoniae 19A isolation	Blood and pleural fluid	Blood	Cerebrospinal fluid	Blood
Antibiotic susceptibility	Susceptibile to penicillin	Susceptibile to penicillin	Penicillin and ceftriaxone resistant	Penicillin and ceftriaxone resistant
Length of stay (day)	21	14	65	14
Outcome	Survived	Survived	Survived	Survived

PCV: Pneumococcal conjugate vaccines, MODS: Multiorgan dysfunction syndrome.