Long-term influenza antibodies profiles in previously vaccinated and non-vaccinated adults

Figures & data

Figure 1. CONSORT diagram for patient selection and samplings.

Table 1. Demographic and clinic characteristics of patients included in the study.

	Previously vaccinated/non-vaccinated group
	V (n = 550)	NV (n = 272)	p-value
Age, yrs (mean, CI95%)	42.2 (41.2–43.0)	44.3 (43.8–44.9)	.0000
Sex (%, male)	413 (75.1%)	202 (74.3%)	.0660
Asthma	24 (4.4%)	8 (2.9%)	.3211
Cardiovascular diseases	10 (1.8%)	1 (0.4%)	.0885
Diabetes	17 (3.1%)	1 (0.4%)	.0121
Arterial Hypertension	27 (4.9%)	4 (1.5%)	.0148
AutoImmune/Inflamatory	24 (4.3%)	4 (1.4%)	.0314

Figure 2. Evolution of the seroprotection rate against the four human influenza viruses type A and B in the group of workers who had been vaccinated at least the previous season (V), and in those who had never been vaccinated against influenza (NV). ****, p < .0001.

Figure 3. Evolution of the GMTs against the four human influenza viruses type A and B in the group of workers who had been vaccinated at least the previous season (V), and in those who had never been vaccinated against influenza (NV). *, p < .05; **, p > .01; ****, p < .0001.

Figure 4. Seroconversion rate (SCR) against the four human influenza viruses type A and B in the group of workers who had been vaccinated at least the previous season (V), and in those who had never been vaccinated against influenza (NV). H1, A(H1N1)pdm09; H3, A(H3N2); BV, B/Victoria; BY, B/Yamagata; ****, p < .0001.

Figure 5. Logistic regression of hemagglutinating antibody titers as a function of the age of the individuals included in the study. V, vaccinated against influenza at least the previous season; NV, never vaccinated against influenza; LR, Logistic Regression; BV, B/Victoria; BY, B/Yamagata.

Figure 6. Log2 HA GMTs for V and NV groups against each influenza A and B virus analyzed for the different pathologies recorded in the study subjects. V, vaccinated against influenza at least the previous season; NV, never vaccinated against influenza; BV, B/Victoria; BY, B/Yamagata.

Data availability statement

The data that support the findings of this study are available from the corresponding author upon reasonable request.