A bibliometric analysis of vaccination against atherosclerosis

Figures & data

Figure 1. Flow chart.

Figure 2. Analysis of annual publications a) Main information. b) Analysis of annual scientific production.

Figure 3. Distribution map of countries. a) the Country collaboration map. b) the proportion of SCP and MCP in the top ten countries ranked by publication output. SCP: single country publications. MCP: multiple country publications.

Table 1. Top 10 contributing countries/regions related to atherosclerosis vaccine.

Country	TP	Rank	Country	TC
USA	113	1	USA	7660
CHINA	52	2	SWEDEN	1793
NETHERLANDS	34	3	NETHERLANDS	1504
SWEDEN	32	4	UNITED KINGDOM	929
UNITED KINGDOM	28	5	GERMANY	771
AUSTRALIA	19	6	CHINA	769
IRAN	19	7	CANADA	701
GERMANY	15	8	AUSTRALIA	619
ITALY	15	9	GREECE	520
JAPAN	13	10	AUSTRIA	515

TP: total publications. TC: total citations.

Figure 4. Distribution map of authors. a) Three-Field Plot-country, institution, author. b) Author’s production over time.

Table 2. The most influential authors in the field of atherosclerosis vaccine.

Rank	Author	TP	Author	TC	Author	H-index
1	Nilsson, J	28	Nilsson, J	294	Nilsson, J	20
2	Shah, PK	16	Fredrikson, GN	203	Hansson, GK	13
3	Fredrikson, GN	14	Hansson, GK	174	Ley, K	12
4	Hansson, GK	14	Ley, K	140	Fredrikson, GN	12
5	Ley, K	14	Witztum, JL	119	Kuiper, J	10
6	Kuiper, J	13	Björkbacka, H	116	Liu, JJ	10
7	Wu, J	13	Kuiper, J	115	Shah, PK	10
8	Liu, JJ	12	Liu, JJ	108	Netea, MG	8
9	Chyu, KY	9	Wu, J	105	Riksen, NP	8
10	Banach, M	8	Van Berkel, TJC	102	Wu, J	8

Figure 5. Core sources by Bradford’s Law. The vertical axis: number of articles, the horizontal axis: journals.

Table 3. The top 10 journals related to atherosclerosis vaccine.

Rank	Journal	TP	JCR	IF 2022
1	Vaccine	23	Q2	5.5
2	Atherosclerosis	21	Q2	5.3
3	Arteriosclerosis Thrombosis and Vascular Biology	16	Q1	8.7
4	Circulation	14	Q1	37.8
5	Cardiovascular Research	8	Q1	10.9
6	Circulation Research	7	Q1	20.1
7	Current Pharmaceutical Design	7	Q3	3.1
8	Current Opinion in Lipidology	6	Q2	4.4
9	European Heart Journal	6	Q1	39.3
10	Frontiers in Immunology	6	Q1	7.3

JCR: journal citation reports. IF: impact factor.

Table 4. Top 10 highest citation publications in the field of atherosclerosis vaccine.

Paper	Year	Journal	TC	Author
Immunity and Inflammation in Atherosclerosis^Citation16	2019	Circulation Research	827	Wolf, D
T Follicular Helper Cell Biology: A Decade of Discovery and Diseases^Citation17	2019	Immunity	741	Crotty, S
Age-dependent dysregulation of innate immunity^Citation18	2013	Nature Reviews Immunology	709	Shaw, AC
Pneumococcal vaccination decreases atherosclerotic lesion formation: molecular mimicry between Streptococcus pneumoniae and oxidized LDL^Citation19	2003	Nature Medicine	582	Binder, CJ
Inflammation and atherosclerosis – Novel insights into plaque formation and destabilization^Citation20	2006	Stroke	382	Stoll, G
Acute systemic inflammation increases arterial stiffness and decreases wave reflections in healthy individuals^Citation21	2005	Circulation	369	Vlachopoulos, C
Association Between Influenza Vaccination and Cardiovascular Outcomes in High-Risk Patients A Meta-analysis^Citation22	2013	Jama-Journal of the American Medical Association	358	Udell, JA
Inflammation, Immunity, and Infection in Atherothrombosis JACC Review Topic of the Week^Citation23	2018	Journal of the American College of Cardiology	332	Libby, P
Vaccine-induced antibodies inhibit CETP activity in vivo and reduce aortic lesions in a rabbit model of atherosclerosis^Citation24	2000	Arteriosclerosis Thrombosis and Vascular Biology	260	Rittershaus, CW
The immune system and aging: a review^Citation25	2014	Gynecological Endocrinology	249	Castelo-Branco, C

Figure 6. Visualization of keywords. a) the density visualization of keywords. b) the cluster map of keywords.

Figure 7. Theme analysis map. a) Trend topic map. b) Thematic map.

Wolf D, Ley K. Immunity and inflammation in atherosclerosis. Circ Res. 2019;124(2):315–27. doi:10.1161/CIRCRESAHA.118.313591.

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Crotty S. T follicular helper cell biology: a decade of discovery and diseases. Immunity. 2019;50(5):1132–48. doi:10.1016/j.immuni.2019.04.011.

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Shaw AC, Goldstein DR, Montgomery RR. Age-dependent dysregulation of innate immunity. Nat Rev Immunol. 2013;13(12):875–87. doi:10.1038/nri3547.

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Binder CJ, Hörkkö S, Dewan A, Chang M-K, Kieu EP, Goodyear CS, Shaw PX, Palinski W, Witztum JL, Silverman GJ, et al. Pneumococcal vaccination decreases atherosclerotic lesion formation: molecular mimicry between Streptococcus pneumoniae and oxidized LDL. Nat Med. 2003;9(6):736–43. doi:10.1038/nm876.

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Stoll G, Bendszus M. Inflammation and atherosclerosis: novel insights into plaque formation and destabilization. Stroke. 2006;37(7):1923–32. doi:10.1161/01.STR.0000226901.34927.10.

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Vlachopoulos C, Dima I, Aznaouridis K, Vasiliadou C, Ioakeimidis N, Aggeli C, Toutouza M, Stefanadis C. Acute systemic inflammation increases arterial stiffness and decreases wave reflections in healthy individuals. Circulation. 2005;112(14):2193–200. doi:10.1161/CIRCULATIONAHA.105.535435.

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Udell JA, Zawi R, Bhatt DL, Keshtkar-Jahromi M, Gaughran F, Phrommintikul A, Ciszewski A, Vakili H, Hoffman EB, Farkouh ME, et al. Association between influenza vaccination and cardiovascular outcomes in high-risk patients: a meta-analysis. JAMA. 2013;310(16):1711–20. doi:10.1001/jama.2013.279206.

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Libby P, Loscalzo J, Ridker PM, Farkouh ME, Hsue PY, Fuster V, Hasan AA, Amar S. Inflammation, immunity, and infection in atherothrombosis: JACC review topic of the week. J Am Coll Cardiol. 2018;72(17):2071–81. doi:10.1016/j.jacc.2018.08.1043.

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Rittershaus CW, Miller DP, Thomas LJ, Picard MD, Honan CM, Emmett CD, Pettey CL, Adari H, Hammond RA, Beattie DT, et al. Vaccine-induced antibodies inhibit CETP activity in vivo and reduce aortic lesions in a rabbit model of atherosclerosis. Arterioscler Thromb Vasc Biol. 2000;20(9):2106–12. doi:10.1161/01.ATV.20.9.2106.

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Castelo-Branco C, Soveral I. The immune system and aging: a review. Gynecol Endocrinol. 2014;30(1):16–22. doi:10.3109/09513590.2013.852531.

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Data availability statement

The data supporting the results of this study can be obtained from the corresponding authors upon reasonable request.