Comprehensive COMPARE database reduces allergenic risk of novel food proteins

Figures & data

Figure 1. Cumulative number of each sequence type added to COMPARE database from 2018 through 2022.

Table 1. Unique additions to COMPARE database with most unique member representing closely related groups of added sequences (largest E-value for alignment with closest preexisting target)

ID by Year	Amino acid			Pereexisting	Percent	Percent
2018	length	Species	Common name	target	similarity	idenity	overlap	E-value
ADV71357.1	411	Protobothrops mucrosquamatus	Snake Venom	AAK96887.1	58.6%	27.6%	58	1.10E-01
BAG88472.1	221	Oryza sativa Japonica Group	Japanese rice	AHA36627.1	51.7%	23.3%	172	1.10E-03
BAV90601.1	128	Dermatophagoides farinae	American house dust mite	AAA99805.1	62.5%	31.2%	32	6.80E-01
BAW03243.1	254	Liposcelis bostrychophila	Booklouse	CAD20556.1	59.6%	27.0%	89	2.10E-01
L7UZ85.1	885	Dermatophagoides farinae	American house dust mite	ACL36923.1	57.9%	23.0%	152	1.00E-04
NP_001036878.1	227	Bombyx mori	Silk Worm	ACY01951.1	60.9%	26.4%	110	2.90E+00
XP_015646887.1	333	Oryza sativa Japonica Group	Japanese rice	Q25641.1	50.0%	25.7%	136	3.00E+00
AK242260.1	150	Oryza sativa Japonica Group	Japanese rice	CAA26385.1	56.7%	34.8%	141	3.80E-05
BAH01262.1	156	Oryza sativa Japonica Group	Japanese rice	AAA34287.1	63.8%	40.5%	116	1.50E-06
2019
ATI08932.1	227	Dermatophagoides pteronyssinus	European House Dust Mite	CAF25232.1	74.2%	48.4%	31	1.20E+00
COMPARE010	556	Chamaecyparis obtusa	Hinoki Cypress Or False Cypress	None	--	--	--	--
COMPARE013	147	Dermatophagoides farinae	American House Dust Mite	AAR21073.1	58.3%	30.0%	60	4.20E-01
Q4W1G2	112	Triticum aestivum	Bread Wheat	AEE98392.1	55.6%	37.5%	72	4.40E-01
ARQ16442.1	595	Artemisia sieversiana	Wormwood; Mugwort	CAB01591.1	56.4%	27.7%	94	5.10E-01
2020
ACT37323.1	221	Stachybotrys chartarum	Black mold	AAL79931.1	61.1%	33.3%	54	1.80E-01
ADM53099.1	565	Staphylococcus aureus	Bacteria	ABL09307.1	69.6%	24.6%	69	3.40E-02
BAF43535.1	84	Anisakis simplex	herring worm	ABD51779.1	59.4%	34.4%	64	2.80E-06
CAA67128.1	503	Triticum aestivum	bread wheat	AAG40331.1	64.6%	29.2%	48	1.30E+00
CAY85463.1	112	Triticum aestivum	bread wheat	CAA31395.4	55.5%	22.7%	110	4.30E-03
NP_001138311.1	163	Apis mellifera	honey bee	BAJ78222.1	55.7%	34.4%	61	9.20E-01
QAT18643.1	391	Dermatophagoides pteronyssinus	European house dust mite	AAC63045.1	66.2%	32.5%	77	9.00E-03
QAT18644.1	396	Dermatophagoides pteronyssinus	European house dust mite	2103117A	67.7%	45.2%	31	2.80E-01
XP_392204.2	318	Apis mellifera	honey bee	Q7M4I5.1	45.9%	25.3%	146	2.60E-01
ACS49840.1	643	Glycine max	soybean	AAL79930.1	58.9%	32.2%	90	1.50E-02
2021
QBP14757.1	844	Dermatophagoides farinae	House dust mite	None	--	--	--	--
QFI57017.1	847	Scylla paramamosain	Green mud crab	CAA73038.1	60.0%	41.7%	60	7.70E-02
QIJ32297.1	179	Crassostrea angulata	Portuguese oyster	ABB89298.1	63.4%	30.5%	82	3.80E-02
QDO73345.1	264	Prunus dulcis	Almond	AAF18269.1	59.6%	33.8%	151	2.90E-04
AAD32205.1	168	Prunus armeniaca	Apricot	AEE98392.1	60.6%	40.6%	175	5.70E-06
2022
P62927	130	Pisum sativum	pea	B3EWP4.1	61.7%	30.0%	60	2.90E-01