Effect of Novel Gasotransmitter hydrogen sulfide on renal fibrosis and connexins expression in diabetic rats

Figures & data

Figure 1. Pathological changes in diabetic rats in each group. (A: Control Group, B: STZ Group, C : STZ+H₂S Group, D : H₂S Group).

Figure 2. Expression of Collagen II in diabetic rats in each group. (A: Control Group, B: STZ Group, C: STZ+H₂S Group, D: H₂S Group).

Table 1. Content of Ualb and 24 h urinary microalbumin excretion in each group.

Groups	24 h urinary protein(Ualb)	24 h urinary microalbumin excretion
Control Groups	11.8 ± 3.3	0.5 ± 0.3
STZ Groups	44.5 ± 6.4^a	13.0 ± 2.6^a
STZ+H2S Groups	26.6 ± 6.1^b	5.9 ± 2.4^b
H2S Groups	12.6 ± 4.0	0.6 ± 0.3

(The values are presented as mean ± SEM, ^aP < 0.01 vs Control group; ^bP < 0.01 vs STZ group).

Figure 3. Expression of hydroxyproline in diabetic rats in each group. (**P < 0.01 vs Control group; ^##P < 0.01 vs STZ group.

Figure 4. Expressions of CX40, CX43 and CX45 in diabetes rats in each group (normalized by GAPDH; **P < 0.01 vs Control group, ^##P < 0.01 vs STZ group).

Figure 5. Expression of MMPs and TIMP in the kidney tissues of each group (normalized by GAPDH; **P < 0.01 vs Control group, ^##P < 0.01 vs STZ group).