miR-25 mediates metastasis and epithelial–mesenchymal-transition in human esophageal squamous cell carcinoma via regulation of E-cadherin signaling

Figures & data

Figure 1. Expression of miR-25 in ESCC tissues and its relation with survival.

Table 1. Correlation between E-cadherin, lymph node metastasis and miR-25 expression.

			miR-25 expression
Features		Number	Low	High	p-value
E-cadherin	Negative	60	33	27	0.0016
	Positive	19	12	7
Lymph node metastasis	No	35	21	14	0.028
	Yes	44	24	20

The industry composition follows the CSRC’s industry coding system in 2001. Manufacturing (labeled C) is divided into ten categories because more than 60% of the sample firms are manufacturers. We omit the banking and insurance industry (labeled I) in our sample.

Figure 2. MiR-25 regulated the migration, invasion but not apoptosis in ESCC cells.

Figure 3. Immunohistochemical staining of E-cadherin.

Figure 4. Effect of miR-25 on E-cadherin genes in Ec-109 and KYSE-510 cells.

Figure 5. Down-regulation of miR-25 or up-regulation of miR-25 in cells having undergone EMT.

Figure 6. Effect of miR-25 lung metastasis in mice.