Relationship between hepatocellular carcinoma and depression via online database analysis

Figures & data

Figure 1. The top-6 of GO enrichment and KEGG pathway enrichment. Count means how many genes fall on the biological function/signal pathway. -Log(PValue): calculate the -Log10 value of P value for easy display in the figure

Figure 2. PPI network. (a): The 199 common genes. (b) Network of cluster-1 gene

Figure 3. Gene expressed in hepatocellular carcinoma group and normal group. Validation of the gene expression of APOE (a), HGF (b), IGF1 (c), SERPINE1 (d), and VEGFA (e). The cutoff was set to |log2 fold change (FC)| ≥1, and p < 0.01. *p < 0.01

Figure 4. Overall survival analysis of the expression level of IGF1, IL1A, CXCL8, VEGFA, and SERPINE1 in hepatocellular carcinoma on GEPIA website. CXCL8 (a), IGF1 (b), IL1A (c), SERPINE1 (d), and VEGFA (e)

Table 1. Drugs acting on VEGFA and SERPINE1

Number	Drug	Gene	Score	Pubmed ID
1	Vandetanib	VEGFA	0.08	None found
2	Ranibizumab	VEGFA	23.96	18046235
3	Pegaptanib sodium	VEGFA	8.71	23953100
4	Carboplatin	VEGFA	0.11	26194361
5	Sildenafil	VEGFA	0.67	23007311
6	Lenalidomide	VEGFA	0.27	None found
7	Fenofibrate	VEGFA	0.28	11356390
8	Cisplatin	VEGFA	0.06	24090479
9	Phenytoin	VEGFA	0.21	15458527
10	Irinotecan	VEGFA	0.25	20125120
11	Minocycline	VEGFA	1.02	11875741
13	Bevacizumab	VEGFA	2.23	18182667
14	Oxaliplatin	VEGFA	0.47	24090479
15	Cilostazol	VEGFA	0.67	11524048
17	Fluorouracil	VEGFA	0.17	2400479
18	Enalapril	VEGFA	0.44	26002049
19	Gliclazide	VEGFA	3.11	17602961
20	Regorafenib	VEGFA	0.16	None found
21	Sunitinib	VEGFA	0.2	22948895
22	Sorafenib	VEGFA	0.2	22736425
23	Gentamicin	VEGFA	0.38	14986132
24	Capecitabine	VEGFA	0.36	20125120
25	Docetaxel	VEGFA	0.21	25111199
26	Leucovorin	VEGFA	0.47	20125120
27	Anistreplase	SERPINE1	1.4	17963464
28	Alteplase	SERPINE1	0.2	17963464
29	Orlistat	SERPINE1	0.42	11410822
30	Epirubicin	SERPINE1	0.14	16444429
31	Fibrinolysin, human	SERPINE1	0.35	None found
32	Citalopram	SERPINE1	0.12	18794724
33	Tenecteplase	SERPINE1	0.7	14564902
34	Reteplase	SERPINE1	1.4	17963464
35	Nimodipine	SERPINE1	0.2	11486117
36	Urokinase	SERPINE1	1.47	12709915
37	Copper	SERPINE1	0.03	21280128
38	Captopril	SERPINE1	0.25	9152782
39	Fluoxetine	SERPINE1	0.12	18794724
40	Levothyroxine	SERPINE1	0.38	16075920
41	Vasopressin	SERPINE1	0.25	7482412
42	Cetrorelix	SERPINE1	1.05	16391860
43	Defibrotide	SERPINE1	0.84	12745658
44	Dexamethasone	SERPINE1	0.05	18285546
45	Hydrochlorothiazide	SERPINE1	0.11	11836266

Data availability statement

In this article, we used four databases and a web page mapping tool, as listed below:

pubmed2ensembl (http://pubmed2ensembl.ls.manchester.ac.uk).

VENNY (https://bioinfogp.cnb.csic.es/tools/venny/).

DAVID (https://david.ncifcrf.gov/).

STRING (http://string-db.orgis).

GEPIA (http://gepia.cancer-pku.cn/).

DGIdb (http://www.dgidb.org/search).