Prediction of clinical prognosis in cutaneous melanoma using an immune-related gene pair signature

Figures & data

Table 1. Prognostic signature information about 41 constructed IRGPs

IRG 1	IRG 2	Coefficient	IRG 1	IRG 2	Coefficient
CD8A	CETP	−0.07	IDO1	TGFB3	−0.03
FCER1G	PTGDS	−0.01	IRF1	SEMA6A	−0.21
HLA-DQB1	S100A8	−0.16	IRF1	MET	−0.11
HLA-DQB1	CDH1	−0.02	JUN	SEMA6A	−0.06
HSPA2	CX3CL1	0.15	GNLY	SEMA4A	−0.03
HSPA2	FGFRL1	0.05	BPHL	CMTM8	0.01
CXCL14	RSAD2	0.02	MARCO	PLAUR	−0.02
CXCL1	ITK	0.02	CCL28	TRIM22	0.03
CCL8	APLNR	−0.17	IRF7	PIK3CD	−0.06
CCL8	TUBB3	−0.04	PDGFRB	TNFSF13B	0.02
S100A9	STAT1	0.04	GBP2	LTBR	−0.13
S100A9	RARRES3	0.01	CCR1	RAC3	−0.01
S100A8	IFIH1	0.10	CD79B	LTB	0.02
SLC22A17	CRABP2	−0.11	RAC3	SEMA3B	0.04
APOBEC3G	ANGPTL2	−0.01	RAC3	FGFRL1	0.04
PLAU	RARRES3	0.01	CD72	EDNRA	−0.06
NOX4	EDNRA	−0.12	IFITM1	GPI	−0.001
CRABP2	CYBB	0.09	SEMA3C	SEMA6A	−0.05
CYBB	CD79B	−0.01	TNC	CLEC11A	−0.07
IFIH1	BMPR2	−0.01	IL17D	SCG2	0.10
IDO1	EDNRA	−0.03

Figure 1. Time-dependent ROC curve for IRGPI at 5 years in the TCGA-CM cohort

Figure 2. Efficacy evaluation of constructed IRGPI risk model. (a) Kaplan-Meier survival curve of TCGA cohort. (b) Kaplan-Meier survival curve of GSE65904 cohort. Univariate and multivariate Cox regression analysis of the clinicopathological features in TCGA (c) and GSE65904 (d) cohorts

Figure 3. The infiltration level of immune cells in the constructed IRGPI risk model. (a) Summary of the 22 tumor-infiltrating immune cells’ abundance estimated by CIBERSORT analysis. p-values are based on t-test (*p< 0.05, ***p< 0.001). (b) The boxplot shows the distribution of specific immune cells in two risk subgroups from the TCGA cohort

Figure 4. Gene set enrichment analysis (GSEA) between high- and low- IRGPI risk subgroups. The results show that 13 cancer hallmark gene sets are enriched in the low IRGPI risk subgroup (FDR < 0.002)

Figure 5. Functional enrichment analysis of 82 immune signature genes. (a) Top 10 classes of GO enrichment terms in biological process (BP), cellular component (CC), and molecular function (MF). (b) Top 10 classes of KEGG enrichment terms. In each bubble plot, the size of the dot represents the number of enriched genes