Oral squamous cell carcinoma (OSCC)-derived exosomal MiR-221 targets and regulates phosphoinositide-3-kinase regulatory subunit 1 (PIK3R1) to promote human umbilical vein endothelial cells migration and tube formation

Figures & data

Table 1. Sequences of amplification primer

Gene		Sequence (5'–3')
miR-221	Forward	ACCTGGCATACAATGTAG
	Reverse	GAACATGTCTGCGTATCTC
U6	Forward	UUCUCCGAACGUGUCACGUTT
	Reverse	UGACACGUUCGGAGAATT
PIK3R1	Forward	CGCCTCTTCTTATCAAGCTCGTG
	Reverse	GAAGCTGTCGTAATTCTGCCAGG
GAPDH	Forward	GGAGCGAGATCCCTCCAAAAT
	Reverse	GGCTGTTGTCATACTTCTCATGG

Figure 1. Decreased PIK3R1 expression in OSCC tissue

Figure 2. Elevated miR-221 expression in OSCC

Figure 3. Exosome-mediated miR-221 negatively regulated PIK3R1 expression

Figure 4. MiR-221 targeted and negatively regulated PIK3R1

Figure 5. OSCC-derived exosomal miR-221 promotes HUVEC migration

Figure 6. OSCC-derived exosomal miR-221 promotes HUVEC tube formation