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Research Paper

Construction of lncRNA-related ceRNA regulatory network in diabetic subdermal endothelial cells

ORCID Icon &
Pages 2592-2602 | Received 30 Mar 2021, Accepted 26 May 2021, Published online: 14 Jun 2021

Figures & data

Table 1. The differentially expressed lncRNAs in GSE92724

Figure 1. Workflow of the present study

Figure 1. Workflow of the present study

Figure 2. Differentially expressed mRNAs and lnRNAs in GSE92724. (a) the volcano plot of the differentially expressed mRNAs. (b) the volcano plot of the differentially expressed lncRNAs. (c) the heatmap of the differentially expressed mRNAs. (d) the heatmap of the differentially expressed lncRNAs. the red dots indicated up-regulated genes and the blue dots indicated down-regulated ones. the gray dots indicated genes which are not differentially expressed

Figure 2. Differentially expressed mRNAs and lnRNAs in GSE92724. (a) the volcano plot of the differentially expressed mRNAs. (b) the volcano plot of the differentially expressed lncRNAs. (c) the heatmap of the differentially expressed mRNAs. (d) the heatmap of the differentially expressed lncRNAs. the red dots indicated up-regulated genes and the blue dots indicated down-regulated ones. the gray dots indicated genes which are not differentially expressed

Figure 3. Functional enrichment analysis of DEmRNA. (a) GO enrichment analysis. (b) KEGG pathway analysis

Figure 3. Functional enrichment analysis of DEmRNA. (a) GO enrichment analysis. (b) KEGG pathway analysis

Table 2. Subcellular localization of DElncRNAs predicted in the lncLocator database

Figure 4. Construction of ceRNA network. Red diamonds indicated lncRNAs, yellow triangles indicated miRNAs and blue rectangles indicated mRNAs. Gray edges indicated the lncRNA-miRNA-mRNA interactions

Figure 4. Construction of ceRNA network. Red diamonds indicated lncRNAs, yellow triangles indicated miRNAs and blue rectangles indicated mRNAs. Gray edges indicated the lncRNA-miRNA-mRNA interactions

Figure 5. Functional enrichment analysis of the ceRNA network. (a) GO enrichment analysis. (b) KEGG pathway analysis. (c) PPI analysis. Edges indicated the protein-protein interactions

Figure 5. Functional enrichment analysis of the ceRNA network. (a) GO enrichment analysis. (b) KEGG pathway analysis. (c) PPI analysis. Edges indicated the protein-protein interactions

Table 3. The differentially expressed genes in ceRNA (node degree ≥ 6)

Figure 6. Conduction of key ceRNA sub-network. (a) MSC-AS1-associated ceRNA sub-network. (b) the LINC01550-associated ceRNA sub-network. Red diamonds indicated lncRNAs, yellow triangles indicated miRNAs and blue rectangles indicated mRNAs. Gray edges indicated the lncRNA-miRNA-mRNA interactions

Figure 6. Conduction of key ceRNA sub-network. (a) MSC-AS1-associated ceRNA sub-network. (b) the LINC01550-associated ceRNA sub-network. Red diamonds indicated lncRNAs, yellow triangles indicated miRNAs and blue rectangles indicated mRNAs. Gray edges indicated the lncRNA-miRNA-mRNA interactions
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