Pharmacological mechanism of mylabris in the treatment of leukemia based on bioinformatics and systematic pharmacology

Figures & data

Table 1. The effective components of Mylabris screened using TCMSP database

No	Name	Compound	OB (%)	DL
1	BM1	linoleic acid	41.90	0.14
2	BM2	oleic acid	33.13	0.14
3	BM3	3-Phenyl-4-azafluorene	32.90	0.23
4	BM4	octadec-7-enoic acid	33.13	0.14
5	BM5	Cantharidin	51.23	0.10

OB, bioavailability; DL, drug-like property.

Figure 1. Interaction diagram between active ingredients and potential targets

Red circle indicates active ingredients, yellow box indicates target.

Figure 2. Intersection of mylabris target genes and leukemia disease genes

Figure (a) indicates the intersection states of mylabris effective components and leukemia-related genes. Figure (b) indicates the intersection leukemia disease genes obtained from Pharmgkb, TTD and OMIM databases.

Figure 3. PPI network interaction among intersection targets

The larger the circle is, the larger the degree value is; the redder the color is, the more important the node is; and the thicker the line between the nodes is, the stronger the interaction is.

Figure 4. GO enrichment analysis of 8 potential targets

Green corresponds to biological process (BP), orange corresponds to cellular composition (CC), and blue corresponds to molecular function (MF). The X axis represents the significance of enrichment, the larger the value, the more obvious, and the Y axis represents the gene term. P < 0.001 indicates significant enrichment.

Figure 5. KEGG pathway enrichment analysis of potential acting genes

The Y axis represents the corresponding pathway, the X axis represents the significance of enrichment, the larger the more significant, the redder the color, the more obvious the enrichment, and the size of the ball represents the amount of genes contained. P< 0.001 indicates significant enrichment

Figure 6. Active ingredient-target-path diagram

Green spherical nodes represent the active components of mylabris, blue spherical nodes represent mylabris, blue square nodes represent effective targets, and yellow heptagonal nodes represent signal pathways.

Data availability statement

All of the datasets analyzed were acquired from the traditional Chinese medicine system pharmacology (TCMSP) database (https://tcmspw.com/tcmsp.php), Online Mendelian Inheritance in Man (OMIM) database (http://www.omim.org/), Therapeutic Target Database (TTD) database (http://www.db.idrblab.net/ttd/), PharmGKB database (https://www.pharmgkb.org/) and GeneCards database (https://www.genecards.org).