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Research Paper

Analysis of regulatory effect of miR-149-5p on Sphingosine-1-phosphate receptor 2 of pericytes and its neuroprotective molecular mechanism after acute cerebral ischemia reperfusion in rats

, , , , , , , , & show all
Pages 3348-3357 | Received 14 Jan 2021, Accepted 19 Jun 2021, Published online: 05 Jul 2021

Figures & data

Figure 1. Frame diagram of the main contents of this study

Figure 1. Frame diagram of the main contents of this study

Figure 2. Primary BMPs identified by immunofluorescence co-staining of α-SMA and PDGFR-β

Figure 2. Primary BMPs identified by immunofluorescence co-staining of α-SMA and PDGFR-β

Figure 3. Changes of S1PR2 expression in pericytes of MCAO model rats

(A: changes of S1PR2 mRNA level in pericytes detected by q RT-PCR; B: protein expression of S1PR2 detected by Western blot; C: image of S1PR2 protein expression.)
Figure 3. Changes of S1PR2 expression in pericytes of MCAO model rats

Figure 4. Changes of S1PR2 expression in pericytes of control group and test group at different time points after MCAO modeling

Figure 4. Changes of S1PR2 expression in pericytes of control group and test group at different time points after MCAO modeling

Figure 5. Detection of MMP9 protein content

(A: staining results of MMP9 protein expression in rat brain tissue, a: the control group; b: the test group; B: comparison of MMP9 protein content in brain tissue between the two groups, * indicated significant difference compared with the control group, P < 0.05)
Figure 5. Detection of MMP9 protein content

Figure 6. Comparison of SODs mRNA levels between test group and control group

(* indicated significant difference compared with the control group, P < 0.05)
Figure 6. Comparison of SODs mRNA levels between test group and control group

Figure 7. Comparison of SODs enzyme activity between the two groups

Figure 7. Comparison of SODs enzyme activity between the two groups