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Research Paper

Optimization of GPC3-specific chimeric antigen receptor structure and its effect on killing hepatocellular carcinoma cells

, , , , , & show all
Pages 3674-3683 | Received 22 Apr 2021, Accepted 26 Jun 2021, Published online: 14 Jul 2021

Figures & data

Figure 1. Study design

Figure 1. Study design

Figure 2. Diagrams of different GPC3-CAR structures

Figure 2. Diagrams of different GPC3-CAR structures

Figure 3. GPC3-CAR expression plasmid for lentiviral preparation

Figure 3. GPC3-CAR expression plasmid for lentiviral preparation

Figure 4. Expression of different GPC3-CAR structures on the cell surface

Figure 4. Expression of different GPC3-CAR structures on the cell surface

Figure 5. Cytotoxicity activity of T cells expression different GPC3-CAR structures to HepG2 cells

Figure 5. Cytotoxicity activity of T cells expression different GPC3-CAR structures to HepG2 cells

Figure 6. Cytotoxicity activity of NK cells expressing different GPC3-CAR structures to HepG2 cells

Figure 6. Cytotoxicity activity of NK cells expressing different GPC3-CAR structures to HepG2 cells

Table 1. Secretion of IFN-γ (pg/mL) after stimulating GPC3-CAR-T or GPC3-CAR-NK cells with GPC3