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Research Paper

Comprehensive Analysis of Monocarboxylate Transporter 4 (MCT4) expression in breast cancer prognosis and immune infiltration via integrated bioinformatics analysis

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Pages 3850-3863 | Received 03 Apr 2021, Accepted 30 Jun 2021, Published online: 16 Jul 2021

Figures & data

Figure 1. The expression profiles of MCT1 and MCT4 in tumor and normal tissues

(A) The expression signatures of MCT4 and MCT1 in multiple cancers when compared with normal tissues. (B) The comparison of MCT1 and MCT4 expression levels in BC and normal tissues.
Figure 1. The expression profiles of MCT1 and MCT4 in tumor and normal tissues

Figure 2. The expression pattern of MCT4 in different subtypes of BC using the GOBO dataset (n = 1881)

Figure 2. The expression pattern of MCT4 in different subtypes of BC using the GOBO dataset (n = 1881)

Figure 3. The expression profile of MCT4 in different subtypes of BC using the merged microarray datasets (n = 10,001)

The expression profile of MCT4 is patterned by (A) PR state, (B) ER state, (C) ER & PR state, (D) HER2 state, (E) basal-like state, (F) PAM50 subtypes, (G) NPI grade, (H) SBR grade.NPI: Nottingham Prognostic Index (a clinicopathological tool for BC patients to stratify the prognostic risk); SBR: Scarff-Bloom-Richardson grade (histologic grading system for BC patients as a prognostic factor).
Figure 3. The expression profile of MCT4 in different subtypes of BC using the merged microarray datasets (n = 10,001)

Figure 4. MCT4 expression signature from RNA-seq level exploiting merged RNA-seq datasets (n = 4712)

The expression profile of MCT4 in BC ranges from (A) PR state, (B) ER state, (C) ER & PR state, (D) HER2 state, (E) basal-like state, (F) PAM50 subtypes, (G) NPI grade, (H) SBR grade.NPI: Nottingham Prognostic Index (a clinicopathological tool for BC patients to stratify the prognostic risk); SBR: Scarff-Bloom-Richardson grade (histologic grading system for BC patients as a prognostic factor).
Figure 4. MCT4 expression signature from RNA-seq level exploiting merged RNA-seq datasets (n = 4712)

Figure 5. The kaplan-meier survival curves of high and low MCT4 expression in BC through the kaplan-meier plotter database. the RFS in (a) PR+ BC, (b) PR- BC, (c) ER+ BC, (d) ER- BC, (e) HER2+ BC, (f) HER2- BC, (g) basal-like subtype, (h) luminal A subtype, (i) luminal B subtype. RFS: relapse-free survival; HR: hazard ratio

Figure 5. The kaplan-meier survival curves of high and low MCT4 expression in BC through the kaplan-meier plotter database. the RFS in (a) PR+ BC, (b) PR- BC, (c) ER+ BC, (d) ER- BC, (e) HER2+ BC, (f) HER2- BC, (g) basal-like subtype, (h) luminal A subtype, (i) luminal B subtype. RFS: relapse-free survival; HR: hazard ratio

Figure 6. The kaplan-meier survival curves of high and low MCT4 expression in BC through the bc-GenExMiner v4.5

The DFS in (A) entire BC cohort, (B) PR+ BC, (C) PR- BC, (D) ER+ BC, (E) ER- BC, (F) HER2 enriched subtype, (G) basal-like subtype, (H) luminal A subtype, (I) luminal B subtype. DFS: disease free survival; 95% CI: 95% confidence interval.
Figure 6. The kaplan-meier survival curves of high and low MCT4 expression in BC through the bc-GenExMiner v4.5

Figure 7. The biological functions of MCT4 showed in enrichment results

Figure 7. The biological functions of MCT4 showed in enrichment results

Figure 8. The relationship of MCT4 and immune infiltration in BC

Figure 8. The relationship of MCT4 and immune infiltration in BC

Figure 9. The intersection of MCT4 related genes and central carbon metabolism related genes

Figure 9. The intersection of MCT4 related genes and central carbon metabolism related genes

Figure 10. The relationship of MCT4, PKM2, and HK3

Figure 10. The relationship of MCT4, PKM2, and HK3

Figure 11. The expression signatures of (a) HK3 and (b) PKM2 in GOBO (n = 1,881)

Figure 11. The expression signatures of (a) HK3 and (b) PKM2 in GOBO (n = 1,881)
Supplemental material

Supplemental Material

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