https://orcid.org/0000-0002-7867-1539
Figures & data
Figure 1. (a) As showed in Venn diagram assay, all candidate, mapped targets of calycosin and BPA-related OS were identified and produce network map using shared targets. (b) After further bioinformatics analysis, all 9 core targets of calycosin in the treatment of BPA-related OS were identified accordingly
Figure 2. (a) After enrichment analyses, top GO-based functional processes, including bone, immunity, inflammation, hormone and cancer, were revealed. (b) Other top KEGG-based molecular mechanisms of calycosin to treat BPA-related OS, including immunity, hormone, cancer and signaling, were uncovered
Figure 3. By using integrated analysis, network visualization of calycosin-target-BP-KEGG-BPA/OS was produced and highlighted
Figure 4. The core targets enriched in KEGG signaling pathway were identified by suing R-language software, as shown in red marks
Figure 5. (a) The binding energy data in core genes were showed in details. (b) Molecular docking findings revealed the biological structure features of core proteins/targets in details
