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Research Paper

Regulating COX10-AS1 / miR-142-5p / PAICS axis inhibits the proliferation of non-small cell lung cancer

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Pages 4643-4653 | Received 18 Jun 2021, Accepted 14 Jul 2021, Published online: 29 Jul 2021

Figures & data

Table 1. Basic information of data set

Table 2. Screening results of differentially expressed genes

Figure 1. Map of differentially expressed genes in four mRNA datasets. GSE136043 data set (a), GSE103512 data set (b), GSE98929 data set (c), GSE146460 data set (d), in which the red dots are up-regulated genes and the green dots are down-regulated genes

Figure 1. Map of differentially expressed genes in four mRNA datasets. GSE136043 data set (a), GSE103512 data set (b), GSE98929 data set (c), GSE146460 data set (d), in which the red dots are up-regulated genes and the green dots are down-regulated genes

Table 3. LogFC value of core gene

Figure 2. Cross analysis of differentially expressed genes

Figure 2. Cross analysis of differentially expressed genes

Figure 3. Enrichment analysis of differentially expressed gene pathways and PPI network. (a): PPI network of core genes. (b): General set enriches chord graph. PPI, Protein–Protein Interaction

Figure 3. Enrichment analysis of differentially expressed gene pathways and PPI network. (a): PPI network of core genes. (b): General set enriches chord graph. PPI, Protein–Protein Interaction

Figure 4. Construction of ceRNA network. (a): mRNA targets predicted from miRNAs. (b): Prediction of lncRNA associated miRNA

Figure 4. Construction of ceRNA network. (a): mRNA targets predicted from miRNAs. (b): Prediction of lncRNA associated miRNA

Figure 5. Sensitivity analysis of PAICS. (a): Survival contribution of multiple genes in multiple cancer types. (b): The impact of PAICS on the survival of LUAD

Figure 5. Sensitivity analysis of PAICS. (a): Survival contribution of multiple genes in multiple cancer types. (b): The impact of PAICS on the survival of LUAD

Figure 6. The effect of COX10-AS1/miR-142-5p/PAICS axis on the proliferation of NSCLC cells. (a): Annexin V-FITC/PI apoptosis detection and lactic acid content detection. (b): miR-142-5p/ PAICS interaction was detected. (c): Regulation of COX10-AS1/miR-142-5p on PAICS gene and protein expression

Figure 6. The effect of COX10-AS1/miR-142-5p/PAICS axis on the proliferation of NSCLC cells. (a): Annexin V-FITC/PI apoptosis detection and lactic acid content detection. (b): miR-142-5p/ PAICS interaction was detected. (c): Regulation of COX10-AS1/miR-142-5p on PAICS gene and protein expression