Figures & data
Table 1. Concentration data of frequently detected antibiotics in different environmental compartments during 2011–2021
Table 2. Toxicity data of antibiotics to non-target aquatic organisms
Table 3. Identified transformation of antibiotics
Tran NH, Chen H, Reinhard M, et al. Occurrence and removal of multiple classes of antibiotics and antimicrobial agents in biological wastewater treatment processes. Water Res. 2016;104:461–472. Dinh QT, Moreau-Guigon E, Labadie P, et al. Occurrence of antibiotics in rural catchments. Chemosphere. 2017;168:483–490. Kairigo P, Ngumba E, Sundberg LR, et al. Occurrence of antibiotics and risk of antibiotic resistance evolution in selected Kenyan wastewaters, surface waters and sediments. Sci Total Environ. 2020;720:137580. Chen K, Zhou JL. Occurrence and behavior of antibiotics in water and sediments from the Huangpu River, Shanghai, China. Chemosphere. 2014;95:604–612. Matongo S, Birungi G, Moodley B, et al. Pharmaceutical residues in water and sediment of Msunduzi River, KwaZulu-Natal, South Africa. Chemosphere. 2015;134:133–140. Östman M, Lindberg RH, Fick J, et al. Screening of biocides, metals and antibiotics in Swedish sewage sludge and wastewater. Water Res. 2017;115:318–328. Yao L, Wang Y, Tong L, et al. Occurrence and risk assessment of antibiotics in surface water and groundwater from different depths of aquifers: a case study at Jianghan Plain, central China. Ecotoxicol Environ Saf. 2017;135:236–242. Gray AD, Todd D, Hershey AE. The seasonal distribution and concentration of antibiotics in rural streams and drinking wells in the piedmont of North Carolina. Sci Total Environ. 2020;710:136286. Zhang R, Zhang G, Zheng Q, et al. Occurrence and risks of antibiotics in the Laizhou Bay, China: impacts of river discharge. Ecotoxicol Environ Saf. 2012;80:208–215. Zhou LJ, Ying GG, Liu S, et al. Occurrence and fate of eleven classes of antibiotics in two typical wastewater treatment plants in South China. Sci Total Environ. 2013;452-453:365–376. Zhang G, Lu S, Wang Y, et al. Occurrence of antibiotics and antibiotic resistance genes and their correlations in lower Yangtze River, China. Environ Pollut. 2020;257:113365. Fernandes MJ, Paiga P, Silva A, et al. Antibiotics and antidepressants occurrence in surface waters and sediments collected in the north of Portugal. Chemosphere. 2020;239:124729. Archundia D, Duwig C, Lehembre F, et al. Antibiotic pollution in the Katari subcatchment of the Titicaca Lake: major transformation products and occurrence of resistance genes. Sci Total Environ. 2017;576:671–682. Gozlan I, Rotstein A, Avisar D. Amoxicillin-degradation products formed under controlled environmental conditions: identification and determination in the aquatic environment. Chemosphere. 2013;91:985–992. Solliec M, Roy-Lachapelle A, Gasser MO, et al. Fractionation and analysis of veterinary antibiotics and their related degradation products in agricultural soils and drainage waters following swine manure amendment. Sci Total Environ. 2016;543:524–535. González-Pleiter M, Gonzalo S, Rodea-Palomares I, et al. Toxicity of five antibiotics and their mixtures towards photosynthetic aquatic organisms: implications for environmental risk assessment. Water Res. 2013;47:2050–2064. Magdaleno A, Saenz ME, Juarez AB, et al. Effects of six antibiotics and their binary mixtures on growth of Pseudokirchneriella subcapitata. Ecotoxicol Environ Saf. 2015;113:72–78. Guo J, Selby K, Boxall AB. Comparing the sensitivity of chlorophytes, cyanobacteria, and diatoms to major-use antibiotics. Environ Toxicol Chem. 2016;35:2587–2596. Hagenbuch IM, Pinckney JL. Toxic effect of the combined antibiotics ciprofloxacin, lincomycin, and tylosin on two species of marine diatoms. Water Res. 2012;46:5028–5036. Baumann M, Weiss K, Maletzki D, et al. Aquatic toxicity of the macrolide antibiotic clarithromycin and its metabolites. Chemosphere. 2015;120:192–198. Johansson CH, Janmar L, Backhaus T. Toxicity of ciprofloxacin and sulfamethoxazole to marine periphytic algae and bacteria. Aquat Toxicol. 2014;156:248–258. Geiger E, Hornek-Gausterer R, Sacan MT. Single and mixture toxicity of pharmaceuticals and chlorophenols to freshwater algae Chlorella vulgaris. Ecotoxicol Environ Saf. 2016;129:189–198. Xiong JQ, Kurade MB, Kim JR, et al. Ciprofloxacin toxicity and its co-metabolic removal by a freshwater microalga Chlamydomonas mexicana. J Hazard Mater. 2017;323:212–219. Wang L, Chen Y, Zhao Y, et al. Toxicity of two tetracycline antibiotics on Stentor coeruleus and Stylonychia lemnae: potential use as toxicity indicator. Chemosphere. 2020;255:127011. Seoane M, Rioboo C, Herrero C, et al. Toxicity induced by three antibiotics commonly used in aquaculture on the marine microalga Tetraselmis suecica (Kylin) Butch. Mar Environ Res. 2014;101:1–7. Huang DJ, Hou JH, Kuo TF, et al. Toxicity of the veterinary sulfonamide antibiotic sulfamonomethoxine to five aquatic organisms. Environ Toxicol Pharmacol. 2014;38:874–880. Białk-Bielińska A, Stolte S, Arning J, et al. Ecotoxicity evaluation of selected sulfonamides. Chemosphere. 2011;85:928–933. Pérez-Parada A, Aguera A, Gomez-Ramos Mdel M, et al. Behavior of amoxicillin in wastewater and river water: identification of its main transformation products by liquid chromatography/electrospray quadrupole time-of-flight mass spectrometry. Rapid Commun Mass Spectrom. 2011;25:731–742. Mitchell SM, Ullman JL, Teel AL, et al. pH and temperature effects on the hydrolysis of three beta-lactam antibiotics: ampicillin, cefalotin and cefoxitin. Sci Total Environ. 2014;466-467:547–555. Wang XH, Lin AY. Phototransformation of cephalosporin antibiotics in an aqueous environment results in higher toxicity. Environ Sci Technol. 2012;46:12417–12426. Buchicchio A, Bianco G, Sofo A, et al. Biodegradation of carbamazepine and clarithromycin by Trichoderma harzianum and Pleurotus ostreatus investigated by liquid chromatography - high-resolution tandem mass spectrometry (FTICR MS-IRMPD). Sci Total Environ. 2016;557-558:733–739. Batchu SR, Panditi VR, O’Shea KE, et al. Photodegradation of antibiotics under simulated solar radiation: implications for their environmental fate. Sci Total Environ. 2014;470-471:299–310. Zhang W, Qiu L, Gong A, et al. Isolation and characterization of a high-efficiency erythromycin A-degrading Ochrobactrum sp. strain. Mar. Pollut Bull. 2017;114:896–902. Mitchell SM, Ullman JL, Teel AL, et al. Hydrolysis of amphenicol and macrolide antibiotics: chloramphenicol, florfenicol, spiramycin, and tylosin. Chemosphere. 2015;134:504–511. Wammer KH, Korte AR, Lundeen RA, et al. Direct photochemistry of three fluoroquinolone antibacterials norfloxacin, ofloxacin, and enrofloxacin. Water Res. 2013;47:439–448. Porras J, Bedoya C, Silva-Agredo J, et al. Role of humic substances in the degradation pathways and residual antibacterial activity during the photodecomposition of the antibiotic ciprofloxacin in water. Water Res. 2016;94:1–9. Maia AS, Ribeiro AR, Amorim CL, et al. Degradation of fluoroquinolone antibiotics and identification of metabolites/transformation products by liquid chromatography-tandem mass spectrometry. J Chromatogr A. 2014;1333:87–98. Ahmad I, Bano R, Musharraf SG, et al. Photodegradation of norfloxacin in aqueous and organic solvents: a kinetic study. J Photochem Photobiol A. 2015;302:1–10. Peterson JW, Gu B, Seymour MD. Surface interactions and degradation of a fluoroquinolone antibiotic in the dark in aqueous TiO2 suspensions. Sci Total Environ. 2015;532:398–403. Jin X, Xu H, Qiu S, et al. Direct photolysis of oxytetracycline: influence of initial concentration, pH and temperature. J Photochem Photobiol A. 2017;332:224–231. Liao X, Zou R, Li B, et al. Biodegradation of chlortetracycline by acclimated microbiota. Process SafEnviron Prot. 2017;109:11–17. Deng Y, Mao Y, Li B, et al. Aerobic degradation of Sulfadiazine by Arthrobacter spp.: kinetics, pathways, and genomic characterization. Environ Sci Technol. 2016;50:9566–9575. Liao X, Li B, Zou R, et al. Antibiotic sulfanilamide biodegradation by acclimated microbial populations. Appl Microbiol Biotechnol. 2016;100:2439–2447. Koba O, Golovko O, Kodesova R, et al. Antibiotics degradation in soil: a case of clindamycin, trimethoprim, sulfamethoxazole and their transformation products. Environ Pollut. 2017;220:1251–1263. Khaleel ND, Mahmoud WM, Hadad GM, et al. Photolysis of sulfamethoxypyridazine in various aqueous media: aerobic biodegradation and identification of photoproducts by LC-UV-MS/MS. J Hazard Mater. 2013;244-245:654–661. Bonvin F, Omlin J, Rutler R, et al. Direct photolysis of human metabolites of the antibiotic sulfamethoxazole: evidence for abiotic back-transformation. Environ Sci Technol. 2013;47:6746–6755. Gong H, Chu W. Determination and toxicity evaluation of the generated products in sulfamethoxazole degradation by UV/CoFe2O4/TiO2. J Hazard Mater. 2016;314:197–203.