Figures & data
Figure 1. Schedule of animal experiments
Figure 2. The expression level of GPR17 and Olig1 in PVL rats was negatively related. a. The gene expression level of GPR17 and Olig1 was detected by RT-PCR (##p < 0.01 vs. sham). b. The expression level of GPR17 and Olig1 in PVL rats on Day 1 post-modeling was determined by Western blotting. c. The expression level of GPR17 and Olig1 in PVL rats on Day 3 post-modeling was determined by Western blotting. d. The expression level of GPR17 and Olig1 in PVL rats on Day 7 post-modeling was determined by Western blotting
Figure 3. The knockdown of GPR17 contributed to the repair and regeneration of myelin sheath post-PVL. The ultrastructure of brain tissue isolated from each animal was visualized by TEM
Figure 4. GPR17 suppressed the migration of OPCs by downregulating Olig1. a. Their migration ability was evaluated by a wound healing assay. b. The gene expression levels of GPR17 and Olig1 were determined by RT-PCR. c. The protein expression levels of GPR17 and Olig1 were measured by Western blotting (**p < 0.01 vs. sham, #p < 0.05 vs. PVL, ##p < 0.01 vs. PVL)
