The Effect of Zbxz23ir-21 NANO(nanomaterials) Delivery Vector on Apoptosis and PTEN(phosphatase and tensin homolog deleted on chromosome ten)/PI3K(Intracellular phosphatidylinositol kinase)/AKT(related to the A and C kinase) in Children with CHOLESTEATOMA in Middle Ear

Figures & data

Figure 1. Cell viability at different RUBONE concentrations

Figure 2. Apoptosis of cells treated with different components

Figure 3. MiR-34a expression level

Table 1. Expression levels of Bcl-2, Cdk6 and CyclinD1 mRNA

	Bcl-2	CDK6	CyclinD1mRNA
CTR	0.98	0.98	0.98
BC-NPs	0.96	0.99	0.97
Free RUBONE	0.095	0.29	0.31
RC-NPs	0.12	0.46	0.58

Figure 4. The volumes of tumors

Figure 5. Expression levels of miR-34a, Bcl-2, CyclinD1 and Cdk6 in tumor tissues

Table 2. Expression of p-AKT in CHOLESTEATOMA cells of middle ear in children

Group	N	p-AKT					Positive rate
		-	+	++	+++	%/	$x^2$	p
Experience group	52	9	18	16	9	82.69	22.11
Control group	20	15	4	1	0	22.12

Table 3. Expression of PTEN in middle ear CHOLESTEATOMA

Group	N	PTEN					Positive rate
		-	+	++	+++	%	$x^2$	p
Experience group	52	32	11	7	2	39.21	12.06
Control group	20	3	7	6	4	85.12

Table

Abbreviation	Full name
Bcl-2	B-cell lymphoma-2
EGFR	epidermal growth factor receptor
NSCLC	nonsmall-cell lung cancer