Figures & data
Figure 1. Bodyweight of mice treated orally with BEO
Figure 2. Effect of topical treatment with BEO (25, 50, 70, and 100%) on multiple-dose skin irritation. A: The skin irritation score of mice after topical application of BEO (25, 50, 70, and 100%). B: Skin sections in the group were treated with (25, 50, 70, and 100%) on day 14. (a) Epidermal thickening, (b) Epidermal thickening with keratinocytes proliferation
Figure 3. Effect of topical treatment with BEO (12.5, 25, and 50%) on multiple-dose eye-irritation
Figure 4. Effect of BEO (2.6, 4.4, and 6.1 mg/kg) on a number of writhing movements induced by glacial acetic acid. (a) number of writhing movements in 20 min, (b) Paw grip-strength (gf). Data are expressed as mean ± standard deviation (n = 10), ***p < 0.001, ****p < 0.0001, compared with the model control
Figure 5. Effect of BEO on serum expression of PGE2 (a) and TRPM8 (b) in the mouse glacial acetic acid-induced writhing pain model. Data are expressed as mean ± standard deviation (n = 10), ***p < 0.001, ****p < 0.0001, compared with model control
