Noncoding RNAs and hyperthermic intraperitoneal chemotherapy in advanced gastric cancer

Figures & data

Table 1. Related noncoding RNAs in gastric cancer of this review

Type of ncRNAs	Expression	Putative roles	Pathway	Targets	Ref
lncRNAs
LINC00152	Upregulated	Promote proliferation and colony formation	EMT	E-cadherin	[39]
HOTAIR	Upregulated	Lmphatic metastasis	H3K27 methylation	H3K27	[53]
DKFZP434K028, RPL34-AS1	Downregulated	Potential biomarker	Unknown	MYRF	[47]
LINC01133	Downregulated	EMT/ metastasis	Wnt/β-catenin	miR-106a-3p/ APC	[54]
XLOC_006753	Upregulated	Promote drug resistance	mTOR/PI3K/AKT signaling	Unknown	[55]
lncR-D63785	Downregulated	Promote drug resistance	mTOR/PI3K/AKT signaling	miR-422/MEF2D	[56]
ZFAS1	Upregulated	Promote proliferation and migration	EMT	KLF2 and NKD2	[57]
Lnc-GNAQ-6:1	Downregulated	Potential biomarker	Unknown	Unknown	[58]
lncSLC2A12-10:1	Upregulated	Potential biomarker	Unknown	Unknown	[59]
LINC00483	Upregulated	Promote invasion and migration	Unknown	miR-490-3p/MAPK1	[60]
lncRNA HCP5	Upregulated	Promote proliferation, invasion, and migration	Unknown	miR-299-3p/SMAD5	[62]
LINC00240	Upregulated	Promote proliferation and migration	Unknown	miR-338-5p/METTL3	[63]
LINC01320	Upregulated	Promote aggressive phenotype	Unknown	miR-495-5p/RAB19	[64]
CERS6-AS1	Upregulated	Promote proliferation, migration and invasion	Unknown	Unknown	[65]
LINC00511	Upregulated	Promote proliferation and migration	Unknown	microRNA-625-5p/STAT3	[66]
PCED1B-AS1	Upregulated	Promote proliferation, migration, invasion and EMT	Unknown	microRNA-215-3p/C-X-C motif chemokine receptor 1	[67]
LINC00649	Upregulated	Promote proliferation, migration and EMT	YAP1/Hippo pathway	miR-16-5p	[68]
NR2F1-AS1	Upregulated	Promote proliferation, invasion and migration	Unknown	SPI1/ST8SIA1	[69]
AL139002.1	Upregulated	Promote proliferation, migration, invasion, and EMT	Unknown	microRNA-490-3p Hepatitis A Virus Cellular Receptor 1	[70]
LINC00265	Upregulated	Promote proliferation	Unknown	microRNA-144-3p/Chromobox 4	[71]
MYLK-AS1	Upregulated	Promote proliferation, migration, and invasion	Unknown	LATS2	[72]
BC031243	Upregulated	CRS + HIPEC	Unknown	Unknown	[107]
RP11-356I2.2	Upregulated	CRS + HIPEC	Unknown	Unknown	[107]
miRNAs
miR-199a-3p	Upregulated	Promote invasion and migration	Unknown	ETNK1, ZHX1	[45]
miR-1, miR-34	Downregulated	Inhibit drug resistance	Unknown	Sorcin	[46]
miR-100-3p	Downregulated	Inhibit proliferation and apoptosis	Bax/Bcl2/Caspase3	BMPR2	[75]
miR-221	Upregulated	lymph node metastasis	p-JAK2, p-STAT3	SOCS3	[76]
miR-423-5p	Upregulated	lymph node metastasis	Unknown	SUFU	[77]
miR-3189-3p	Downregulated	CRS + HIPEC	Unknown	CFL2	[106]
miR-1825	Downregulated	CRS + HIPEC	Unknown	Unknown	[106]
miR-32-3p, miR-3149, miR-4297	Upregulated	CRS + HIPEC	Unknown	Unknown	[106]
miR-1299	Upregulated	CRS + HIPEC	Unknown	ETS1	[106]
miR-218	Upregulated	CRS + HIPEC	SMO signaling	Gli2	[107]
miR-8-3p	Upregulated	HIPEC	AMPK signaling	PPP2R5B	[110]
miR-23a	Downregulated	Heat-stressed	Unknown	NOXA	[112]
miR-10b	Downregulated	Hyperthermia	Unknown	Hoxd10	[113]
miR-15b	Downregulated	Hyperthermia	DYNLT1/Caspase-3/Caspase-9 signaling	DYNLT1	[113]
miR-106a	Upregulated	Promote growth	Unknown	Smad7	[78]
miR-425	Upregulated	Promote cell viability, migration, and invasion	Unknown	Dickkopf-related protein-3	[79]
miR −1269b	Downregulated	Inhibit proliferation, migration, and invasion	Unknown	METTL3	[80]
miR-130a-3p	Upregulated	Promote proliferation, migration, and invasion	Unknown	GCNT4/TGF-beta1/SMAD3	[81]
circRNAs
ciRS-7	Upregulated	Inhibit the invasion	PTEN/PI3K/AKT Signaling	miR-7	[48]
circ-PVT1	Upregulated	Promote drug resistance	Unknown	miR-124/ZEB1	[84]
circ-MTHFD2	Upregulated	Promote drug resistance	Unknown	miR-124	[85]
circ-OXCT1	Downregulated	Suppress EMT progress	Unknown	miR-136/SMAD4	[86]
circCCDC9	Downregulated	Inhibit the proliferation, migration and invasion	Unknown	miR-6792-3p/CAV1	[87]
circ-RanGAP1	Upregulated	promotes GC progression	Unknown	miR-877-3p/VEGFA	[88]
circSHKBP1	Upregulated	Promote proliferation, invasion and migration	miR-582-3p/HUR/VEGF	miR-582-3p	[89]
circRNA_102231	Upregulated	Promote proliferation and invasion	Unknown	IRTKS	[90]
hsa_circ_0000751	Downregulated	Inhibit progression, migration, and invasion	Unknown	miR-488/UQCRC2	[91]
circPRKDC	Upregulated	Promote cell viability, metastasis, and EMT	Unknown	IRS2/microRNA-493-5p	[92]
circ-HN1	Upregulated	Promote proliferation, migration, and invasion	miR-485-5p/GSK3A pathway	Unknown	[93]
hsa_circ_0000117	Upregulated	Promote proliferation and invasion	Unknown	microRNA-337-3p/signal transducer and activator of transcription 3 axis	[94]
circCOL6A3_030	Upregulated	Promote migration	Unknown	Unknown	[95]
circ0005654	Upregulated	Promote proliferation, migration and invasion	Unknown	miR-363/sp1/myc/Wnt/β-catenin axis	[96]

Figure 1. Noncoding RNAs relevant to cell gene functions in gastric cancer.

Figure 2. Involvement of noncoding RNAs in the classical signaling pathways, such as PI3K/AKT/mTOR, Wnt/β-catenin, NF-κB, MAPK, and Notch, and in the inflammatory signaling pathways in gastric cancer.

Figure 3. Changes in the levels of noncoding RNAs and cell functions in gastric cancer after treatment with HIPEC.

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