https://orcid.org/0000-0002-2813-1702
Figures & data
Table 1. Easily absorbed active components and their basic parameters in S. marianum.
Table 2. Hepatoprotective on NAFLD targets of active components from S. marianum
Figure 1. The diagram and distribution map of degree value and betweenness centrality associated with active components of S. marianum-prediction target network.
Figure 2. Common targets in Venn diagram.
Figure 3. The diagram and distribution map of degree value and betweenness centrality associated with active components of S. marianum–hepatoprotective-NAFLD target network.
Table 3. Core targets of S. marianum on NAFLD and their topological characteristics
Figure 4. PPI network of active compounds-hepatoprotective-NAFLD target protein of S. marianum.
Figure 5. KEGG pathway and GO biological process enrichment analysis diagrams.
Figure 6. Annotated map of the target points of the main active components of S. marianum on NAFLD-related signal pathways.
Table 4. The results of molecular docking
Figure 7. Docking pattern of silymarin with the key target molecules.
Figure 8. Effects of silymarin on mice body weights and histopathological changes.
Figure 9. Effects of silymarin on blood lipid and liver function level.
Figure 10. Effects of silymarin on the expression of related proteins of NAFLD.
Supplemental Material
Download PDF (375.2 KB)Data availability statement
The raw data used to support the findings of this study are available from the corresponding author upon request.
