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Bioengineered Volume 14, 2023 - Issue 1
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Research Paper

Diagnostic value of BinaxNOW antigen card for Severe Acute Respiratory Syndrome Coronavirus 2

Yue-Xue Maia Department of Clinical Laboratory Medicine, the Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China;b Department of Clinical Medicine, the Sixth Clinical School of Guangzhou Medical University, Guangzhou, ChinaView further author information
,
Jia-Hao Zhanga Department of Clinical Laboratory Medicine, the Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China;b Department of Clinical Medicine, the Sixth Clinical School of Guangzhou Medical University, Guangzhou, ChinaView further author information
,
Xi-Feng Qiana Department of Clinical Laboratory Medicine, the Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China;b Department of Clinical Medicine, the Sixth Clinical School of Guangzhou Medical University, Guangzhou, ChinaView further author information
,
Ke-Fan Wua Department of Clinical Laboratory Medicine, the Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China;b Department of Clinical Medicine, the Sixth Clinical School of Guangzhou Medical University, Guangzhou, ChinaView further author information
,
Xin Yina Department of Clinical Laboratory Medicine, the Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China;c Department of Pediatrics, the Pediatrics School of Guangzhou Medical University, Guangzhou, ChinaView further author information
,
Zhan-Fu Moa Department of Clinical Laboratory Medicine, the Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China;c Department of Pediatrics, the Pediatrics School of Guangzhou Medical University, Guangzhou, ChinaView further author information
,
Xiao-Ying Zhonga Department of Clinical Laboratory Medicine, the Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China;c Department of Pediatrics, the Pediatrics School of Guangzhou Medical University, Guangzhou, ChinaView further author information
,
Qi-Qing Yea Department of Clinical Laboratory Medicine, the Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China;c Department of Pediatrics, the Pediatrics School of Guangzhou Medical University, Guangzhou, ChinaView further author information
,
Zi-Yuan Yua Department of Clinical Laboratory Medicine, the Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China;d Department of Clinical Medicine, the Third Clinical School of Guangzhou Medical University, Guangzhou, ChinaView further author information
&
Xu-Guang Guoa Department of Clinical Laboratory Medicine, the Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China;d Department of Clinical Medicine, the Third Clinical School of Guangzhou Medical University, Guangzhou, China;e Guangzhou Key Laboratory for Clinical Rapid Diagnosis and Early Warning of Infectious Diseases, KingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou, China;f Guangdong Provincial Key Laboratory of Major Obstetric Diseases, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China;g Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes, the Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, ChinaCorrespondence[email protected]
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Article: 2180221 | Received 17 Apr 2022, Accepted 26 Jul 2022, Published online: 25 Jul 2023

Figures & data

Figure 1. Quality evaluation of the included studies.

Figure 1. Quality evaluation of the included studies.

Figure 2. Forest plots for the combined sensitivity(a), specificity(b), positive LR(c), negative LR(d) of BinaxNOW.

Figure 2. Forest plots for the combined sensitivity(a), specificity(b), positive LR(c), negative LR(d) of BinaxNOW.

Figure 3. Forest plots for the combined diagnostic OR of BinaxNOW(a) and summary receiver operating characteristic curves of COVID-19 infections detected by BinaxNOW(b).

Figure 3. Forest plots for the combined diagnostic OR of BinaxNOW(a) and summary receiver operating characteristic curves of COVID-19 infections detected by BinaxNOW(b).

Table 1. Subgroup analyses for the exploration of factors influencing heterogeneity in the BinaxNOW assay.

Table 2. Weighted meta-regression to assess the effects of various factors on the diagnostic accuracy of the BinaxNOW assay.

Figure 4. Deeks’ funnel plot asymmetry test to assess publication bias in estimates of diagnostic OR for BinaxNOW detection of COVID-19 infections.

Figure 4. Deeks’ funnel plot asymmetry test to assess publication bias in estimates of diagnostic OR for BinaxNOW detection of COVID-19 infections.
Supplemental material

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Data availability statement

All data generated or analyzed during this study are included in this published article.

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