Figures & data
Figure 1. Simvastatin inhibits pathogenic pathways that impair muscle function in dystrophic muscle. Loss of dystrophin increases inflammation, fibrosis, and oxidative stress by NOX2. This leads to muscle damage and progressive weakness. Simvastatin reduces each of these pathways (red arrows), improving muscle health and function.
![Figure 1. Simvastatin inhibits pathogenic pathways that impair muscle function in dystrophic muscle. Loss of dystrophin increases inflammation, fibrosis, and oxidative stress by NOX2. This leads to muscle damage and progressive weakness. Simvastatin reduces each of these pathways (red arrows), improving muscle health and function.](/cms/asset/0b121b48-032a-4652-944e-915d6d8b0a0f/krad_a_1156286_f0001_oc.gif)