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Addendum

Simvastatin offers new prospects for the treatment of Duchenne muscular dystrophy

, , , &
Article: e1156286 | Received 11 Nov 2015, Accepted 12 Feb 2016, Published online: 12 Apr 2016

Figures & data

Figure 1. Simvastatin inhibits pathogenic pathways that impair muscle function in dystrophic muscle. Loss of dystrophin increases inflammation, fibrosis, and oxidative stress by NOX2. This leads to muscle damage and progressive weakness. Simvastatin reduces each of these pathways (red arrows), improving muscle health and function.

Figure 1. Simvastatin inhibits pathogenic pathways that impair muscle function in dystrophic muscle. Loss of dystrophin increases inflammation, fibrosis, and oxidative stress by NOX2. This leads to muscle damage and progressive weakness. Simvastatin reduces each of these pathways (red arrows), improving muscle health and function.