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Addendum

Pathological relationships involving iron and myelin may constitute a shared mechanism linking various rare and common brain diseases

, , , , , , , , , , (for the UK Brain Expression Consortium (UKBEC)) , , , & show all
Article: e1198458 | Received 22 Feb 2016, Accepted 01 Jun 2016, Published online: 07 Jul 2016

Figures & data

Figure 1. Iron labeling by DAB-enhanced Perls' staining in wildtype and Hfe−/−xTfr2mut mouse brain at 3 months of age. Iron is mainly accumulated in myelinated structures and associated cells. Myelin (M), oligodendrocyte (O), blood vessel (V) and black arrows show neurons (N) which do not accumulate appreciable iron even in the Hfe−/−xTfr2mut mouse brain.

Figure 1. Iron labeling by DAB-enhanced Perls' staining in wildtype and Hfe−/−xTfr2mut mouse brain at 3 months of age. Iron is mainly accumulated in myelinated structures and associated cells. Myelin (M), oligodendrocyte (O), blood vessel (V) and black arrows show neurons (N) which do not accumulate appreciable iron even in the Hfe−/−xTfr2mut mouse brain.

Table 1. Myelin-related genes identified as differentially expressed in i. the Hfe−/−xTfr2mut mice in comparison with wildtype mice and ii. NBIA post-mortem basal ganglia samples compared to neurologically healthy control samples. FC: fold change. Asterisks indicate genes that were not reported as myelin-related genes in our previous paper.

Table 2. Some important myelin-related genes identified as differentially expressed in NBIA post-mortem basal ganglia samples compared to neurologically healthy control samples (asterisks indicate newly identified genes).

Supplemental material

KRAD_S_1198458.docx

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