ALSUntangled #61: melatonin

Figures & data

Table 1 Table of evidence for melatonin.

	Grade	Explanation
Mechanism	A	Melatonin treatment can reduce biomarkers of oxidative stress and inflammation in humans with MS and ALS
Pre-clinical	C	Some (but not all) flawed studies in an ALS mouse model suggest benefits
Cases	B	2 patients with validated ALS diagnoses experienced validated improvements (ALS reversals) on cocktails of treatments including melatonin
Trials	U	We found no trials comparing clinical outcomes in PALS on melatonin versus controls
Risks	B	Across many human trials melatonin appears reasonably safe, even at fairly high doses