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Epidemiology

Occupational history associates with ALS survival and onset segment

ORCID Icon, , , , ORCID Icon &
Pages 219-229 | Received 20 May 2022, Accepted 14 Sep 2022, Published online: 03 Oct 2022

Figures & data

Table 1 Participant demographics and results of univariable unadjusted Cox proportional hazards models.

Table 2 Job-years worked with two-digit SOC codes associated with survival: single SOC code models.

Figure 1 Kaplan–Meier survival plot by occupational pesticide exposure. Kaplan–Meier survival plot comparing ALS participants who report occupational exposure to pesticides (blue line; median survival = 1.49 years) versus those who do not report occupational pesticide exposure (red line; median survival = 2.32 years; p value = 0.046).

Figure 1 Kaplan–Meier survival plot by occupational pesticide exposure. Kaplan–Meier survival plot comparing ALS participants who report occupational exposure to pesticides (blue line; median survival = 1.49 years) versus those who do not report occupational pesticide exposure (red line; median survival = 2.32 years; p value = 0.046).

Table 3 Occupational exposure scores associated with survival.

Table 4 SOC codes associated with onset segment.

Figure 2 Onset segment multinomial logistic regression model and distribution. On the left, forest plot of the adjusted multinomial logistic regression models from showing the odds ratio for bulbar and cervical onset with lumbar onset as the reference. On the right, the distribution of each onset segment by exposed and unexposed.

Figure 2 Onset segment multinomial logistic regression model and distribution. On the left, forest plot of the adjusted multinomial logistic regression models from Table 5 showing the odds ratio for bulbar and cervical onset with lumbar onset as the reference. On the right, the distribution of each onset segment by exposed and unexposed.

Table 5 Occupational exposure scores associated with onset segment.

Supplemental material

Supplemental Material

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Data availability statement

Sharing of non-identifiable data will be considered at the reasonable request of a qualified investigator.