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Review

A review of the criteria for non-invasive diagnosis of cardiac transthyretin amyloidosis

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Pages 87-94 | Received 27 Nov 2020, Accepted 01 Mar 2021, Published online: 12 Apr 2021

Figures & data

Figure 1. Transthoracic echocardiogram (TTE) of a patient with cardiac ATTR CM. TTE demonstrating concentric left ventricular hypertrophy (left to right) 4 Chamber view, parasternal and parasternal short axis view.4 Chamber global longitudinal strain demonstrating a ‘bull’s eye pattern’, characteristic of cardiac amyloidosis

Figure 1. Transthoracic echocardiogram (TTE) of a patient with cardiac ATTR CM. TTE demonstrating concentric left ventricular hypertrophy (left to right) 4 Chamber view, parasternal and parasternal short axis view.4 Chamber global longitudinal strain demonstrating a ‘bull’s eye pattern’, characteristic of cardiac amyloidosis

Figure 2. Cardiac MRI of a patient with ATTR CM (left to right) steady-state free precession cine; four chamber, two chamber, three chamber and short axis view demonstrating concentric LV hypertrophy

Figure 2. Cardiac MRI of a patient with ATTR CM (left to right) steady-state free precession cine; four chamber, two chamber, three chamber and short axis view demonstrating concentric LV hypertrophy

Figure 3. Cardiac MRI with phase sensitive inversion recovery reconstruction late gadolinium enhancement images demonstrating A) No LGE B) Sub-endocardial LGE and C) transmural LGE

Figure 3. Cardiac MRI with phase sensitive inversion recovery reconstruction late gadolinium enhancement images demonstrating A) No LGE B) Sub-endocardial LGE and C) transmural LGE

Figure 4. Cardiac MRI short axis steady-state free precession cine (left to right) with corresponding native myocardial T1 map, corresponding myocardial T2 map, corresponding phase sensitive inversion recovery reconstruction late gadolinium enhancement image and corresponding ECV map

Figure 4. Cardiac MRI short axis steady-state free precession cine (left to right) with corresponding native myocardial T1 map, corresponding myocardial T2 map, corresponding phase sensitive inversion recovery reconstruction late gadolinium enhancement image and corresponding ECV map

Figure 5. A) 99mTc labeledlabelled DPD scintigraphy demonstrating Perugini Grade 2 cardiac uptake in a patient with ATTR-CM

Figure 5. A) 99mTc labeledlabelled DPD scintigraphy demonstrating Perugini Grade 2 cardiac uptake in a patient with ATTR-CM
short-legendFigure 5b. B)Diagnostic algorithm for the noninvasivenon-invasive diagnosis of ATTR-CM.