Long-term adverse effects after curative radiotherapy and radical prostatectomy: population-based nationwide register study

Jón Ö. FridrikssonDepartment of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden; Correspondence[email protected]

Yasin FolkvaljonRegional Cancer Center Uppsala Örebro, Uppsala University Hospital, Uppsala, Sweden;

Per NilssonDepartment of Oncology and Radiation Physics, Skåne University Hospital, Lund University, Lund, Sweden;

David RobinsonDepartment of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden; ;Department of Urology, Ryhov Hospital, Jönköping, Sweden;

Ingela Franck-LissbrantDepartment of Oncology and Radiation Physics, Sahlgrenska University Hospital, Gothenburg, Sweden;

Behfar EhdaieDepartment of Surgery, Urology Service, Memorial Sloan-Kettering Cancer Center, New York City, NY, USA;

James A. EasthamDepartment of Surgery, Urology Service, Memorial Sloan-Kettering Cancer Center, New York City, NY, USA;

Anders WidmarkDepartment of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden;

Camilla T. KarlssonDepartment of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden;

Pär StattinDepartment of Surgical Sciences, Uppsala University, Uppsala, Sweden;Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden;

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Figures & data

Table 1. Baseline characteristics of men diagnosed with prostate cancer (PCa) between 1997 and 2012 who received radiotherapy (RT)Table Footnote^a or a radical prostatectomy (RP)Table Footnote^a and their matched PCa-free men in the Prostate Cancer data Base (PCBaSe) 3.0.

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Figure 1. Relative risk of diagnoses indicating adverse effects up to 12 years after treatment for intermediate- and localized high-risk prostate cancer (PCa) vs age-matched prostate cancer-free men. RT: radiotherapy; RP: radical prostatectomy; IR: incidence rate; py: patient-years; RR: relative risk; CI: confidence interval; LUTS: lower urinary tract symptoms; GI: gastrointestinal.

Figure 2. Relative risk of procedures indicating adverse effects up to 12 years after treatment for intermediate- and localized high-risk prostate cancer (PCa) vs age-matched prostate cancer-free men. RT: radiotherapy; RP: radical prostatectomy; IR: incidence rate; py: patient-years; RR: relative risk; CI: confidence interval; GI: gastrointestinal; IRR: incidence risk ratio.

Table 2. Relative risks (RRs) of diagnoses and procedures indicating an adverse effect of treatment for men in all risk categories of prostate cancer (PCa) who received radiotherapy compared to men who underwent a prostatectomy.

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Long-term adverse effects after curative radiotherapy and radical prostatectomy: population-based nationwide register study

Table 1. Baseline characteristics of men diagnosed with prostate cancer (PCa) between 1997 and 2012 who received radiotherapy (RT)Table Footnote^a or a radical prostatectomy (RP)Table Footnote^a and their matched PCa-free men in the Prostate Cancer data Base (PCBaSe) 3.0.

Table 2. Relative risks (RRs) of diagnoses and procedures indicating an adverse effect of treatment for men in all risk categories of prostate cancer (PCa) who received radiotherapy compared to men who underwent a prostatectomy.

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Long-term adverse effects after curative radiotherapy and radical prostatectomy: population-based nationwide register study

Figures & data

Table 1. Baseline characteristics of men diagnosed with prostate cancer (PCa) between 1997 and 2012 who received radiotherapy (RT)Table Footnotea or a radical prostatectomy (RP)Table Footnotea and their matched PCa-free men in the Prostate Cancer data Base (PCBaSe) 3.0.

Table 2. Relative risks (RRs) of diagnoses and procedures indicating an adverse effect of treatment for men in all risk categories of prostate cancer (PCa) who received radiotherapy compared to men who underwent a prostatectomy.

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Table 1. Baseline characteristics of men diagnosed with prostate cancer (PCa) between 1997 and 2012 who received radiotherapy (RT)Table Footnote^a or a radical prostatectomy (RP)Table Footnote^a and their matched PCa-free men in the Prostate Cancer data Base (PCBaSe) 3.0.