Current trends in salivary gland tight junctions

Figures & data

Figure 1. Tight junction localization in salivary glands. This diagram depicts the basic structure of a salivary gland. In it, TJs are represented in contrasting colors on the basis of their localization within the gland (i.e., pink within the acinus, blue in intercalated ducts and yellow in striated ducts) to illustrate changes in TJ composition due to differing functions within various salivary gland compartments. Finally, the inset shows tight junction transmembrane proteins (i.e., occludin, claudins and JAM family members) that are linked to the cytoskeleton via cytoplasmic ZO-1.

Table 1. Tight junction expression in salivary glands. This table summarizes TJs detected to date (both in salivary glands and related cell lines). Abbreviations within it are as follows: SMG: submandibular gland, PG: parotid gland, MSG: Major salivary glands, mSG: minor salivary glands, Par-C10 and Pa4: rat parotid cell lines, HSG: human submandibular cell line and MG: Matrigel.

Claudin-1	Human SMG	Human MSG	Human MSG Human Msg Rat PG		Par-C10 HSG
Claudin-2	Human SMG	Human MSG	Human MSG		SMG-C6 HSG on MG
Claudin-3	Human SMG Rabbit SMG	Human MSG Mouse MSG	Human MSG Mouse MSG		Par-C10 SMG-C6 HSG on MG
Claudin-4	Human SMG	Human MSG	Human MSG Rat PG Mouse SMG		Par-C10 SMG-C6 HSG on MG
Claudin-5	Human SMG			Human MSG Rat MSG
Claudin-6			E mouse SMG
Claudin-7	Human SMG Mouse SMG		Human mSG
Claudin-8		E mouse SMG	E mouse SMG
Claudin-10		E mouse SMG E rat SMG			Par-C10
Claudin-11	Human SMG		Human mSG
Claudin-12	Mouse SMG
Claudin-16		Human MSG	Human MGS
Occludin		Human MSG Human mSG Mouse SMG	Human MSG Human mSG Mouse SMG	Human MSG	Pa-4 Par-C10 HSG on MG
JAM-A		Human MSG	Human MSG		Par-C10 HSG on MG
ZO-1	Human SMG	Human MSG Human mSG Mouse SMG	Human MSG Human mSG Mouse SMG	Human MSG	Par-C10 SMG-C6