Figure 1. The effect of surface charge on nanoparticle–cell interactions. Cationic nanoparticles are more prone to enter the cells by electrostatic attraction of negatively charged cell membrane.
Figure 2. PEGylation of nanoparticles. Uncoated nanoparticles are mainly picked up by macrophages whereas coating of nanoparticles with PEG leads to an enhanced circulation time due to prevention of nanoparticles internalization by macrophages.
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