Figures & data
Figure 1. SEM images of (І) ATV/PVP, (ІІ) EZT/PVP and (ІІІ) ATV/EZT:PVP nano-solid dispersions, (A) and (B) ESs with the drug to polymer ratio of 1:1 and solution concentrations of 10% and 20% (w/v), respectively, (C) and (D) ESs with the drug to polymer ratio of 1:5 and solution concentrations of 10% and 20% (w/v), respectively.
![Figure 1. SEM images of (І) ATV/PVP, (ІІ) EZT/PVP and (ІІІ) ATV/EZT:PVP nano-solid dispersions, (A) and (B) ESs with the drug to polymer ratio of 1:1 and solution concentrations of 10% and 20% (w/v), respectively, (C) and (D) ESs with the drug to polymer ratio of 1:5 and solution concentrations of 10% and 20% (w/v), respectively.](/cms/asset/5ef3ecb3-52e2-4883-a2cb-5dca49c52a41/ianb_a_1202262_f0001_b.jpg)
Figure 2. DSC thermograms of the PVP K30, pure drugs, corresponding physical mixtures (PMs), and electrosprayed samples (ESs) all in 1:1 ratio.
![Figure 2. DSC thermograms of the PVP K30, pure drugs, corresponding physical mixtures (PMs), and electrosprayed samples (ESs) all in 1:1 ratio.](/cms/asset/0e16c8b5-e3da-46e3-884a-8a71170c3939/ianb_a_1202262_f0002_b.jpg)
Figure 3. PXRD patterns of the PVP K30, pure drugs, corresponding physical mixtures (PMs), and electrosprayed samples (ESs) all in 1:1 ratio.
![Figure 3. PXRD patterns of the PVP K30, pure drugs, corresponding physical mixtures (PMs), and electrosprayed samples (ESs) all in 1:1 ratio.](/cms/asset/29390eef-ad74-4510-93b0-47013f316d08/ianb_a_1202262_f0003_b.jpg)
Figure 4. FTIR spectra of the PVP K30, pure drugs, corresponding physical mixtures (PMs), and electrosprayed samples (ESs) all in 1:1 ratio.
![Figure 4. FTIR spectra of the PVP K30, pure drugs, corresponding physical mixtures (PMs), and electrosprayed samples (ESs) all in 1:1 ratio.](/cms/asset/b0e3cc2b-ee5e-41a3-85f1-dbca99a90f4e/ianb_a_1202262_f0004_b.jpg)
Figure 5. Drug release profile of various formulations. Left panel (A) ATV release from ATV/EZT binary mixture (BM—○—), pure drug (—•—), physical mixtures (PM—▵— —□—), and electrosprayed samples (ES—▴— —▪—) all in 1:1 ratio. Right panel (B) EZT release from BM, pure drug, PMs, and ESs as mentioned above. Each point represents mean ± SD (n = 3).
![Figure 5. Drug release profile of various formulations. Left panel (A) ATV release from ATV/EZT binary mixture (BM—○—), pure drug (—•—), physical mixtures (PM—▵— —□—), and electrosprayed samples (ES—▴— —▪—) all in 1:1 ratio. Right panel (B) EZT release from BM, pure drug, PMs, and ESs as mentioned above. Each point represents mean ± SD (n = 3).](/cms/asset/bfcbc457-602a-4535-8b1b-96e70458e4ee/ianb_a_1202262_f0005_b.jpg)