In vitro assessment of non-irritant microemulsified voriconazole hydrogel system

Figures & data

Figure 1. Solubility of voriconazole in various liquid vehicles.

Table 1. Composition of voriconazole microemulsions.

Voriconazole (50 mg)
Oleic acid	Oil (ml)	Smix (ml)	IPM	Oil (ml)	Smix (ml)
O1	2	5	I1	2	3
O2	3	4	I2	3	4
O3	2	5	I3	2	5
O4	3	4	I4	3	4
O5	4	4	I5	4	3
O6	3	5	I6	4	4
O7	2	6	I7	2	4
O8	3	5	I8	3	3
O9	2	5	I9	3	3
O10	2	5	I10	2	4
O11	4	4	I11	1	5
O12	4	5	I12	3	4
O13	3	5	I13	2	5
O14	5	4	I14	2	6
O15	5	3	I15	5	3
O16	3	6	I16	3	4

Figure 2. Drug content in microemulsions.

Figure 3. Percent drug released from microemulsions (O1–O8).

Figure 4. Percent drug released from microemulsions (O9–O16).

Figure 5. Percent drug released from microemulsions (I1–I8).

Figure 6. Percent drug released from microemulsions (I9–I16).

Table 2. Viscosity, pH, globule size, PDI, and Zeta potential of microemulsions.

Microemulsion	Viscosity (cp)	pH	Globule size (nm)	Polydispersity index (PDI)	Zeta potential (mV)
O2	126.54	7.2	30	0.982	1.2
O4	124.21	7.0	65	0.916	−10.7
O6	123.87	7.1	28	0.823	−7.2
O8	125.09	7.2	24	0.998	−4.6

Table 3. Viscosity, in vitro, and ex vivo studies of selected MBH formulations.

		In vitro studies		Ex vivo studies
MBH	Viscosity (cp)	Flux (μg cm^−2 h^−1)	Diffusion coefficient (cm h^−1)	Flux (μg cm^−2 h^−1)	Permeability coefficient (cm h^−1)
O2	250.20	1.836	0.0329	1.787	0.0357
O4	265.06	1.875	0.0375	1.735	0.0347
O6	280.12	1.901	0.0380	1.853	0.0370
O8	240.96	1.908	0.0381	1.986	0.0397

Table 4. Antifungal activity of MBH formulations.

	Zone of inhibition (mm)
MBH	Actinomyces	Candida	Rhizopus	Sacchromyces
Voriconazole (standard)	0.6	0.2	0.5	0.2
MBH O2	0.7	0.3	0.7	0.5
MBH O4	1.2	0.6	1.1	1.3
MBH O6	1.6	0.8	1.4	1.6
MBH O8	2.2	1.1	1.2	1.9