Fabrication and characterization of shape memory polymers based bioabsorbable biomedical drug eluting stent

Figures & data

Table 1. Optimization of bare polymeric stent.

				Critical Processing Variables
Batch Code	PLA (mg)	PLGA (mg)	Chloroform (mL)	Self-expandability (Time in min) (Mean Value)	Thickness (mm) (Mean Value)
V1	500	–	10	18.6 ± 1.56	0.27 ± 0.04
V2	450	50	10	14 ± 0.74	0.26 ± 0.01
V3	400	100	10	11 ± 0.43	0.24 ± 0.01
V4	350	150	10	7.2 ± 0.61	0.26 ± 0.02
V5	300	200	10	5.06 ± 0.48	0.25 ± 0.02
V6	250	250	10	2.3 ± 0.52	0.21 ± 0.05
V7	200	300	10	1.4 ± 0.57	0.18 ± 0.01
V8	150	350	10	1.2 ± 0.24	0.18 ± 0.01
V9	100	400	10	1.1 ± 0.32	0.11 ± 0.06
V10	50	450	10	–
V11	–	500	10	–

Bold value indicates optimized formulation.

Figure 1. Thickness of (a) Drug-loaded polymeric stent (b) Bare polymeric stent.

Figure 2. FTIR spectrum of (a) Drug-loaded polymeric stent (b) PLGA, (c) PLA and (d) Tacrolimus.

Figure 3. DSC thermograms of (a) Physical mixture of tacrolimus and PLA, (b) Tacrolimus and (c) PLA.

Figure 4. FESEM images of (a) Bare PLA-PLGA polymeric stent (b) Tacrolimus-loaded polymeric stent.

Figure 5. Strength of (a) Bare polymeric stent, (b) Drug-loaded polymeric stent.

Figure 6. Cumulative drug release of tacrolimus-loaded polymeric stent.

Figure 7. (a) Original diameter of stent, (b) Before keeping at freezing temperature, (c) After removal from freezing temperature. In-vitro behavior of stent after (d) 1 min, (e) 3 min and (f) 5 min.

Figure 8. (a) Original diameter of polymeric stent after insertion into Goat vessel, Ex-vivo behavior of stent (b) 1 min, (c) 3 min, (d) 5 min.

Figure 9. Hemocompatibility study (a) control untreated RBCs, (b) polymeric stent treated with RBCs.

Figure 10. FESEM images of (a) Bare polymeric stent treated with platelets (b) Drug-loaded polymeric stent treated with platelets.

Figure 11. FESEM images of (a) Drug-loaded polymeric stent incubated in PBS solution (b) Drug-loaded polymeric stent incubated in distilled water (c) Drug-loaded polymeric stent (control).

Figure 12. Bacterial adhesion on materials incubated in approx. 1X10⁸ cells/mL, (a) S. aureus (b) P. aeruginosa after 4 h.

Figure 13. Percent cell viability of drug-loaded polymeric stent.