Recent advances in magnetoliposome for heart drug delivery

Figures & data

Figure 1. A diagram of magnet liposomes is shown.

Figure 2. Schematic diagram of multi-functionalities of magnetioliposomes.

Figure 3. Different nanoparticle heart-targeted delivery systems including magnet lipid nanoparticle are shown.

Table 1. Some of nanoparticles which have been used for heart drug delivery.

Type	Studied by	Structure	Function in Heart
Dendrimers	Bella et al. [54]	Three-dimensional (3D)	Improved cardioprotective potency through theactivation of A3 adenosine receptor (A3AR) on the cardiac muscle cells surface
	Johnson et al. [55]
			Protect the affected cardiac tissue against oxidative stress
Liposomes	Kohane’s group [56]	Vesicular structures with a phospholipid bilayer	liposomal adenosine was able to improve thecardioprotective effects of adenosine againstischemia injury and decrease any its unfavourable systemic effects
Polymeric nanoparticles	Somasuntharam et al. [57]	The size of nanoparticles ranges between 10 and 100 nm	Acid-degradable polyketal particles efficientlydelivered Nox2-siRNA to the affected cardiac sites and improved the heart functions.
Microparticles	Hesford et al. [58].	Spherical structure containing a matrix	The polymeric microparticles loaded with anti-inflammatory drugs has proven to be efficient in the treatment of myocardial infarction and other heart, also to improve the half-life and stability of cardioprotective drugs, such as VEGF

Figure 4. Clinical application of magnet liposome in both in vitro and in vivo assays is shown.

Figure 5. Liposome and magnet nanoparticle as a drug delivery system vehicle to the heart are shown.

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