Dexamethasone reduces serum level of IL-17 in Bleomycin-A5-induced rats model of pulmonary fibrosis

Figures & data

Figure 1. Comparison of scores of alveolar catarrh (A) pulmonary fibrosis (B) in the 3 groups. The score of alveolar catarrh and pulmonary fibrosis was zero in the control group, and there was no significant difference between model group and DEX group.

Table 1. Serum levels of TGF-β1, IL-8, and IL-17 in the 3 groups.

		1st Day	14th Day	28th Day
Control Group	TGF-β1	8.33 ± 1.96	7.89 ± 1.60	9.47 ± 2.08
	IL-8	10.11 ± 1.26	10.08 ± 2.72	9.54 ± 1.86
	IL-17	13.10 ± 3.58	9.88 ± 2.54	11.93 ± 2.51
Model Group	TGF-β1	14.18 ± 2.87	24.98 ± 4.00	15.35 ± 3.57
	IL-8	23.64 ± 3.32	53.05 ± 4.74	36.86 ± 12.36
	IL-17	21.86 ± 3.59	72.90 ± 9.56	35.93 ± 8.08
DEX Group	TGF-β1	14.16 ± 2.41	24.22 ± 3.89	14.90 ± 3.01
	IL-8	21.87 ± 5.30	53.65 ± 6.18	39.20 ± 11.16
	IL-17	20.47 ± 4.66	67.02 ± 6.78	29.50 ± 7.60

The concentration of TGF-β1, IL-8, and IL-17 was measured as pg/ml in the serum. Data are presented as mean ± standard deviation.

Figure 2. The serum levels of TGF-β1 (A), IL-8 (B), and IL-17 (C) at different time points. *p < .05.

Figure 3. The serum level of IL-17 was significantly correlated with TGF-β1 (A) and IL-8 (B).