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Research-article

Antinociceptive synergistic interaction between Achillea millefolium and Origanum vulgare L. extract encapsulated in liposome in rat

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Pages 994-1000 | Received 10 May 2017, Accepted 05 Jul 2017, Published online: 18 Jul 2017

Figures & data

Figure 1. Dose–response curves for the antinociceptive effect of A. millefolium, (A), ORG (B), and A. millefolium–ORG encapsulated in liposome (C) in the second phase of formalin test.

Figure 1. Dose–response curves for the antinociceptive effect of A. millefolium, (A), ORG (B), and A. millefolium–ORG encapsulated in liposome (C) in the second phase of formalin test.

Figure 2. The isobologram antinociceptive synergistic interaction between A. millefolium and ORG extract encapsulated in liposome in the second phase of the formalin test.

Figure 2. The isobologram antinociceptive synergistic interaction between A. millefolium and ORG extract encapsulated in liposome in the second phase of the formalin test.

Table 1. Co-administration drug dose used.

Figure 3. The effect of naloxone (A) and L-NAME (B) on the antinociceptive effect of the A. millefolium and ORG extract encapsulated in liposome combination. Bars are the mean ± SEM for at least six animals. Significantly different (*p < .05) from the co-administration (C), by one-way analysis of variance followed by the Student–Newman–Keuls test.

Figure 3. The effect of naloxone (A) and L-NAME (B) on the antinociceptive effect of the A. millefolium and ORG extract encapsulated in liposome combination. Bars are the mean ± SEM for at least six animals. Significantly different (*p < .05) from the co-administration (C), by one-way analysis of variance followed by the Student–Newman–Keuls test.

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