Development and characterization dual responsive magnetic nanocomposites for targeted drug delivery systems

Figures & data

Scheme 1. Strategies for the preparation of well-defined and triblock terpolymer by RAFT agent.

Figure 1. (a) XRD and (b) FT-IR spectrum of Fe₃O₄ nanoparticles.

Figure 2. FT-IR spectrum of (a) dihydroxyl-terminated PEG (HO-PEG-OH), (b) PEG-RAFT agent, (c) poly [(PMA-PNIPAM)m-b-PEG-b-(PNIPAM-PMA)m] triblock terpolymer and (d) DOX-loaded triblock terpolymer.

Figure 3. GPC traces of poly [(PMA-PNIPAM)m-b-PEG-b-(PNIPAM-PMA)m] triblock terpolymer.

Figure 4. SEM images of (a) pure Fe₃O₄ nanoparticles, (b) poly [(PMA-PNIPAM)m-b-PEG-b-(PNIPAM-PMA)m] triblock terpolymer in the solid state, and TEM images of (c) pure Fe₃O₄ nanoparticles and (d) poly [(PMA-PNIPAM)m-b-PEG-b-(PNIPAM-PMA)m] triblock terpolymer micelle at pH =5.

Figure 5. Magnetic behaviour of (a) Fe₃O₄ nanoparticles and (b) poly [(PMA-PNIPAM)m-b-PEG-b-(PNIPAM-PMA)m]/Fe₃O₄/DOX magnetic nanocomposite.

Figure 6. (a) Temperature dependence of light transmittance of triblock terpolymer solutions (C= 0.2 mg/L, pH = 7.) and (b) pH dependence of light transmittance of triblock terpolymer solutions (C = 0.2 mg/L, 25 °C).

Figure 7. DLS of (a) triblock terpolymer micelles at pH =5, 25 ºC, (b) triblock terpolymer micelles at pH =7, 60 ºC and (c) DOX-loaded triblock terpolymer magnetite nanocomposite at pH =7, 25 °C.

Figure 8. Release of DOX from triblock terpolymer (a) pH =5.8, T = 42 °C, (b) pH =5.8, T = 37 °C, (c) pH =7.4, T = 42 °C and (d) pH =7.4, T = 37 °C.

Figure 9. The cytotoxicity for A549 cells induced by the treatment with DOX-loaded triblock terpolymer/Fe₃O₄ and free DOX with different concentrations for 48 and 72 h.