Figures & data
![](/cms/asset/bb861ae5-1d5b-4fa7-b521-0b8f73703361/ianb_a_1379016_uf0001_c.jpg)
Figure 1. The schematic peptide synthesis of K3W4K3 (a), the schematic synthesis of FITC-labeled K3W4K3 (b) and the schematic synthesis of K3W4K3-EPR conjugate (c).
![Figure 1. The schematic peptide synthesis of K3W4K3 (a), the schematic synthesis of FITC-labeled K3W4K3 (b) and the schematic synthesis of K3W4K3-EPR conjugate (c).](/cms/asset/52911a4c-ae08-40f3-a7fd-34ec8e85e5ed/ianb_a_1379016_f0001_c.jpg)
Table 1. Different cell penetrating peptide amphiphiles (CPPs) synthesized in the present study.
Table 2. The percentage of drug (EPR) loading for different peptide-EPR conjugates (CPPs-EPR).
Figure 2. MTT-based cytotoxicity of different CPPs (a), CPPs-E4 nanoparticles (b) and CPPs-E8 nanoparticles (c) at various concentrations (5, 10 and 25 µM) after 48 h incubation in MCF-7 cell line at 37 °C. Data represent Mean ± SD for six replicates.
![Figure 2. MTT-based cytotoxicity of different CPPs (a), CPPs-E4 nanoparticles (b) and CPPs-E8 nanoparticles (c) at various concentrations (5, 10 and 25 µM) after 48 h incubation in MCF-7 cell line at 37 °C. Data represent Mean ± SD for six replicates.](/cms/asset/dff2efcb-1c8b-46e4-a926-53a5557815dd/ianb_a_1379016_f0002_c.jpg)
Figure 3. Fluorescence microscopy images of MCF-7 cells incubated with FITC-labeled CPPs and their corresponding nanoparticles (CPPs-E8) at concentration of 10 (a) and 50 µM (b), respectively after 2 h incubation at 37 °C.
![Figure 3. Fluorescence microscopy images of MCF-7 cells incubated with FITC-labeled CPPs and their corresponding nanoparticles (CPPs-E8) at concentration of 10 (a) and 50 µM (b), respectively after 2 h incubation at 37 °C.](/cms/asset/29d17c83-7adb-49dc-87db-b25819dc6ca7/ianb_a_1379016_f0003_c.jpg)
Figure 4. Cellular uptake (%) of FITC-CPPs and the corresponding nanoparticles (FITC-CPPs-E8) at different concentration of 10, 25 and 50 µM, respectively after 2 h incubation in MCF-7 cell at 37 °C. Data represent Mean ± SD for three replicates. FITC-CPPs and FITC-CPPs and FITC-CPPs-E8 nanoparticles are presented by solid lines with the symbol of ▪ and dashed lines with the symbol of •, respectively.
![Figure 4. Cellular uptake (%) of FITC-CPPs and the corresponding nanoparticles (FITC-CPPs-E8) at different concentration of 10, 25 and 50 µM, respectively after 2 h incubation in MCF-7 cell at 37 °C. Data represent Mean ± SD for three replicates. FITC-CPPs and FITC-CPPs and FITC-CPPs-E8 nanoparticles are presented by solid lines with the symbol of ▪ and dashed lines with the symbol of •, respectively.](/cms/asset/dd1386fa-28e9-4752-ba91-a5689d6aa36b/ianb_a_1379016_f0004_c.jpg)