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Articles

In vitro and in vivo delivery of gliclazide loaded mPEG-PCL micelles and its kinetic release and solubility study

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Pages 1625-1636 | Received 27 Jul 2017, Accepted 25 Sep 2017, Published online: 03 Nov 2017

Figures & data

Figure 1. (a) Schematic synthesis route of mPEG-PCL copolymer, (b) 1H-NMR spectrum of mPEG-PCL copolymer, and (c) GPC curve of copolymer P5.

Figure 1. (a) Schematic synthesis route of mPEG-PCL copolymer, (b) 1H-NMR spectrum of mPEG-PCL copolymer, and (c) GPC curve of copolymer P5.

Table 1. Molecular characterics of the synthesized copolymers.

Figure 2. AFM image of gliclazide loaded spherical core shell micelles.

Figure 2. AFM image of gliclazide loaded spherical core shell micelles.

Figure 3. Particle size distribution and zeta potential of gliclazide/mPEG-PCL and mPEG-PCL micelles. (a) particle size distribution and (b) zeta potential of gliclazide/mPEG-PCL micelles.

Figure 3. Particle size distribution and zeta potential of gliclazide/mPEG-PCL and mPEG-PCL micelles. (a) particle size distribution and (b) zeta potential of gliclazide/mPEG-PCL micelles.

Figure 4. (a) Excitation spectra of pyrene in water for mPEG-PCL copolymer at various concentrationsand, (b) Intensity ratio I392/I373 of pyrene excitation spectra versus log C for mPEG-PCL copolymer.

Figure 4. (a) Excitation spectra of pyrene in water for mPEG-PCL copolymer at various concentrationsand, (b) Intensity ratio I392/I373 of pyrene excitation spectra versus log C for mPEG-PCL copolymer.

Figure 5. Stability micelles.

Figure 5. Stability micelles.

Table 2. Characterisistic of micelles from the synthesized copolymers.

Table 3. Properties of gliclazide-loaded mPEG-PCL micelles.

Figure 6. FT-IR spectra of (a) gliclazide, (b) gliclazide/mPEG-PCL micelles, and (c) mPEG-PCL.

Figure 6. FT-IR spectra of (a) gliclazide, (b) gliclazide/mPEG-PCL micelles, and (c) mPEG-PCL.

Figure 7. Differential scanning calorimetry (DSC) spectra of (a) gliclazide/mPEG-PCL micelles (b) gliclazide and (c) mPEG-PCL.

Figure 7. Differential scanning calorimetry (DSC) spectra of (a) gliclazide/mPEG-PCL micelles (b) gliclazide and (c) mPEG-PCL.

Figure 8. The release profiles of gliclazide from gliclazide/mPEG-PCL micelles in different release medias.

Figure 8. The release profiles of gliclazide from gliclazide/mPEG-PCL micelles in different release medias.

Figure 9. Solubility of gliclazide.

Figure 9. Solubility of gliclazide.

Figure 10. Effect of gliclazide and gliclazide/mPEG-PCL micelles on fasting blood sugar. All the values are expressed in mean ± SE (n = 6); *p < .05 compared to diabetic rat group; #p < .05 compared to gliclazide rat group.

Figure 10. Effect of gliclazide and gliclazide/mPEG-PCL micelles on fasting blood sugar. All the values are expressed in mean ± SE (n = 6); *p < .05 compared to diabetic rat group; #p < .05 compared to gliclazide rat group.

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