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Artificial Cells, Nanomedicine, and Biotechnology
An International Journal
Volume 46, 2018 - Issue 8
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Articles

Prevention of ischemia-reperfusion lung injury during static cold preservation by supplementation of standard preservation solution with HEMO2life® in pig lung transplantation model

M. GlorionLaboratoire de Chirurgie Expérimentale, Université PARIS XI, Hôpital Marie Lannelongue, Le Plessis Robinson, France; ;Department of Thoracic Surgery and Lung Transplantation, Foch Hospital, Suresnes, France;
,
V. PolardHEMARINA S.A., Morlaix, France;
,
F. FavereauFaculté de Médecine, Université de Poitiers, INSERM U927, Poitiers, France
,
T. HauetFaculté de Médecine, Université de Poitiers, INSERM U927, Poitiers, France
,
F. ZalHEMARINA S.A., Morlaix, France;
,
E. FadelLaboratoire de Chirurgie Expérimentale, Université PARIS XI, Hôpital Marie Lannelongue, Le Plessis Robinson, France;
&
E. SageLaboratoire de Chirurgie Expérimentale, Université PARIS XI, Hôpital Marie Lannelongue, Le Plessis Robinson, France; ;Department of Thoracic Surgery and Lung Transplantation, Foch Hospital, Suresnes, France; Correspondence[email protected]
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Pages 1773-1780 | Received 31 Jul 2017, Accepted 11 Oct 2017, Published online: 25 Oct 2017

Figures & data

Figure 1. Lung HIF1α ratio during ischemia.

Figure 1. Lung HIF1α ratio during ischemia.

Figure 2. Left pulmonary mean arterial pressure MPAP (mmHg). *p < .05; **p < .01; ***p < .001.

Figure 2. Left pulmonary mean arterial pressure MPAP (mmHg). *p < .05; **p < .01; ***p < .001.

Figure 3. Left pulmonary vascular resistance PVR (dynes.s− 1.cm −5 ) *p < .05; **p < .01; ***p < .001.

Figure 3. Left pulmonary vascular resistance PVR (dynes.s− 1.cm −5 ) *p < .05; **p < .01; ***p < .001.

Figure 4. Left lung haematosis: PaO2/FiO2 ratio (mmHg) *p < .05; **p < .01; ***p < .001.

Figure 4. Left lung haematosis: PaO2/FiO2 ratio (mmHg) *p < .05; **p < .01; ***p < .001.

Figure 5. HMG B1 in serum (ratio/H0) *p < .05; **p < .01; ***p < .001.

Figure 5. HMG B1 in serum (ratio/H0) *p < .05; **p < .01; ***p < .001.

Figure 6. TNF-α in serum (ratio/H0) *p < .05; **p < .01; ***p < .001.

Figure 6. TNF-α in serum (ratio/H0) *p < .05; **p < .01; ***p < .001.

Figure 7. NO in serum (ratio/H0) *p < .05; **p < .01; ***p < .001.

Figure 7. NO in serum (ratio/H0) *p < .05; **p < .01; ***p < .001.

Figure 8. Il-8 in BALF (pg/l) *p < .05; **p < .01; ***p < .001.

Figure 8. Il-8 in BALF (pg/l) *p < .05; **p < .01; ***p < .001.

Figure 9. TNF-α in BALF (pg/l) *p < .05; **p < .01; ***p < .001.

Figure 9. TNF-α in BALF (pg/l) *p < .05; **p < .01; ***p < .001.

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