Figures & data
Figure 1. The structure of CD133-DTX LP (A) and the transmission electron microscope of DTX LP (B) and CD133-DTX LP (C) (×97,000).
![Figure 1. The structure of CD133-DTX LP (A) and the transmission electron microscope of DTX LP (B) and CD133-DTX LP (C) (×97,000).](/cms/asset/dc9232fa-0980-48e7-ad35-3ed0ce8875f8/ianb_a_1394874_f0001_c.jpg)
Table 1. The characteristics of different formulations: particle size, entrapment efficiency, polydispersity index and zeta potential (n = 3).
Figure 2. The release profile of free DTX (top line), DTX LP (middle line) and CD133-DTX LP (bottom line) (n = 6).
![Figure 2. The release profile of free DTX (top line), DTX LP (middle line) and CD133-DTX LP (bottom line) (n = 6).](/cms/asset/f1644d76-66f1-4c3b-a22e-2aab55033e9f/ianb_a_1394874_f0002_c.jpg)
Table 2. Physical stability of CD133-DTX LP at 2–8 °C (n = 3).
Figure 3. Confocal images of cellular uptake of free DTX (A), DTX LP (B) and CD133-DTX LP (C) by a 549 cells. Incubation time was 2 h.
![Figure 3. Confocal images of cellular uptake of free DTX (A), DTX LP (B) and CD133-DTX LP (C) by a 549 cells. Incubation time was 2 h.](/cms/asset/bf4933a8-e106-4893-afcb-c24ad6bc25e3/ianb_a_1394874_f0003_c.jpg)
Figure 4. In vitro cytotoxicity analysis of free DTX, DTX LP and CD133-DTX LP on A549 cell lines. Cell viability assay was performed by MTT assay.
![Figure 4. In vitro cytotoxicity analysis of free DTX, DTX LP and CD133-DTX LP on A549 cell lines. Cell viability assay was performed by MTT assay.](/cms/asset/d1d43ee7-b0ae-4926-ae43-cf478f472d1f/ianb_a_1394874_f0004_c.jpg)
Figure 5. Fluorescence images of subcutaneous A-549 tumour-bearing nude mice after intravenous injection of DTX LP and CD133-DTX LP. The circle, the position of the tumour. (A) 2 h after injection. (B) 8 h after injection. (C) Fluorescence image of dissected organs of mice bearing A-549 tumour sacrificed 10 h after intravenous injection. 1, brain; 2, heart; 3, liver; 4, spleen; 5, lung. (D) Fluorescence image of dissected tumours of mice 10 h after intravenous injection of DTX LP and CD133-DTX LP.
![Figure 5. Fluorescence images of subcutaneous A-549 tumour-bearing nude mice after intravenous injection of DTX LP and CD133-DTX LP. The circle, the position of the tumour. (A) 2 h after injection. (B) 8 h after injection. (C) Fluorescence image of dissected organs of mice bearing A-549 tumour sacrificed 10 h after intravenous injection. 1, brain; 2, heart; 3, liver; 4, spleen; 5, lung. (D) Fluorescence image of dissected tumours of mice 10 h after intravenous injection of DTX LP and CD133-DTX LP.](/cms/asset/313c6028-8fa0-4072-b6b1-ea109e58eadc/ianb_a_1394874_f0005_c.jpg)