3,287
Views
16
CrossRef citations to date
0
Altmetric
Research Article

Formulation of sitagliptin-loaded oral polymeric nano scaffold: process parameters evaluation and enhanced anti-diabetic performance

, &
Pages 66-78 | Received 04 Oct 2017, Accepted 24 Nov 2017, Published online: 09 Dec 2017

Figures & data

Table 1. Process variables and their levels for experimental design.

Table 2. Experimental runs obtained from Box–Behnken design and their observed value of particle size (Y1), drug loading (Y2) and %drug release (Y3).

Table 3. Summary of regression analysis for responses [Y1 = particle size (nm), Y2 = drug loading (%), and Y3 = drug release (%)] for fitting to different kinetic models.

Figure 1. (A–D) 3D-response surface plots and 2D contour plot showing the influence of independent variables [eudragit (%), tween 80 (%), and sonication time (minutes)] on particle size (nm) for the SIT-NPs.

Figure 1. (A–D) 3D-response surface plots and 2D contour plot showing the influence of independent variables [eudragit (%), tween 80 (%), and sonication time (minutes)] on particle size (nm) for the SIT-NPs.

Figure 2. (A–D) 3D-response surface plots and 2D contour plot showing the influence of independent variables [eudragit (%), tween 80 (%), and sonication time (minutes)] on drug loading (%) for the SIT-NPs.

Figure 2. (A–D) 3D-response surface plots and 2D contour plot showing the influence of independent variables [eudragit (%), tween 80 (%), and sonication time (minutes)] on drug loading (%) for the SIT-NPs.

Figure 3. (A–D) 3D-response surface plots and 2D contour plot showing the influence of independent variables [eudragit (%), tween 80 (%), and sonication time (minutes)] on drug release (%) for the SIT-NPs.

Figure 3. (A–D) 3D-response surface plots and 2D contour plot showing the influence of independent variables [eudragit (%), tween 80 (%), and sonication time (minutes)] on drug release (%) for the SIT-NPs.

Figure 4. Predicted vs. actual plot showing the influence of independent variables [eudragit (%), tween 80 (%), and sonication time (minutes)] on dependent variables [particle size (nm), drug loading (%) and drug release (%)] for the SIT-NPs.

Figure 4. Predicted vs. actual plot showing the influence of independent variables [eudragit (%), tween 80 (%), and sonication time (minutes)] on dependent variables [particle size (nm), drug loading (%) and drug release (%)] for the SIT-NPs.

Table 4. Experimentally optimized value of formulation SIT-NPopt.

Figure 5. (A–D) Images of SIT-NPopt: (A) Particle size distribution image; (B) Transmission electron micrograph; (C) Scanning electron micrograph; (D) Atomic force microscopy.

Figure 5. (A–D) Images of SIT-NPopt: (A) Particle size distribution image; (B) Transmission electron micrograph; (C) Scanning electron micrograph; (D) Atomic force microscopy.

Figure 6. Comparative in-vitro drug release profile of SIT-NPopt and SIT-Fs.

Figure 6. Comparative in-vitro drug release profile of SIT-NPopt and SIT-Fs.

Table 5. In vitro release kinetics data to different mathematical models for SIT-NPopt and SIT-fs.

Figure 7. Comparative In-vivo antidiabetic activity profile of different treated groups on animal model.

Figure 7. Comparative In-vivo antidiabetic activity profile of different treated groups on animal model.

Figure 8. (A–D) Effect of different temperature with humidity on the stability study data of SIT-NPopt.

Figure 8. (A–D) Effect of different temperature with humidity on the stability study data of SIT-NPopt.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.