Figures & data
Figure 1. Effect of formulation compositions on (A) vesicles size, (B) polydispersity index, (C) zeta potential, (D) entrapment efficiency of TS-loaded vesicles containing bile salt. Formulations F1, F2, F3, F4, F5, F6 contained SoyPC/ NaDC in 9/1, 7/1, 6/1, 5/1, 4/1, 3/1 ratio, respectively. NaDC: sodium deoxycholate; SoyPC: soybean phosphatidylcholine; TS: telmisartan.
![Figure 1. Effect of formulation compositions on (A) vesicles size, (B) polydispersity index, (C) zeta potential, (D) entrapment efficiency of TS-loaded vesicles containing bile salt. Formulations F1, F2, F3, F4, F5, F6 contained SoyPC/ NaDC in 9/1, 7/1, 6/1, 5/1, 4/1, 3/1 ratio, respectively. NaDC: sodium deoxycholate; SoyPC: soybean phosphatidylcholine; TS: telmisartan.](/cms/asset/49ac657e-93fe-4962-b8f8-2c6d2a8d4768/ianb_a_1430700_f0001_c.jpg)
Figure 2. Transmission electron microscopy of TS-loaded optimized formulation F4 contained SoyPC and NaDC in 5/1 ratio. Abbreviations: NaDC, sodium deoxycholate; SoyPC, soybean phosphatidylcholine; TS, telmisartan.
![Figure 2. Transmission electron microscopy of TS-loaded optimized formulation F4 contained SoyPC and NaDC in 5/1 ratio. Abbreviations: NaDC, sodium deoxycholate; SoyPC, soybean phosphatidylcholine; TS, telmisartan.](/cms/asset/0f2e0b53-31a4-4ed5-9202-c4729e24b92b/ianb_a_1430700_f0002_b.jpg)
Table 1. Effects of TS suspension and formulation F4 on kidney function test in streptozotocin-induced diabetic nephropathy rats (mean ± SEM).
Table 2. Effects of TS suspension and formulation F4 on antioxidant enzymes and oxidative stress markers in streptozotocin-induced diabetic nephropathy rats (mean ± SEM).
Figure 3. Effect of TS suspension and formulation F4 on (A) MPO, (B) TNF-α, (C) IL-6 in streptozotocin-induced diabetic nephropathy rats (mean ± SEM). IL-6: interleukin 6; MPO: myeloperoxidase; TNF-α: tumour necrosis factor-α; TS: telmisartan.
![Figure 3. Effect of TS suspension and formulation F4 on (A) MPO, (B) TNF-α, (C) IL-6 in streptozotocin-induced diabetic nephropathy rats (mean ± SEM). IL-6: interleukin 6; MPO: myeloperoxidase; TNF-α: tumour necrosis factor-α; TS: telmisartan.](/cms/asset/7a58f7f5-fc86-4093-bb8b-5b36ec87e039/ianb_a_1430700_f0003_c.jpg)