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Research Article

Controlled release of mitomycin C from PHEMAH–Cu(II) cryogel membranes

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Pages 946-954 | Received 09 Dec 2017, Accepted 08 Feb 2018, Published online: 19 Feb 2018

Figures & data

Table 1. Parameters for cryogel membrane synthesis.

Figure 1. (A) The structure of MAH monomer. (B) The UV-spectrum of MAH–Cu(II)–MMC complex. (C) Hypothetical model for the MAH–Cu(II)–MMC complex.

Figure 1. (A) The structure of MAH monomer. (B) The UV-spectrum of MAH–Cu(II)–MMC complex. (C) Hypothetical model for the MAH–Cu(II)–MMC complex.

Figure 2. FTIR-ATR spectra of MMC-ICM and PHEMACM.

Figure 2. FTIR-ATR spectra of MMC-ICM and PHEMACM.

Figure 3. The SEM images of MMC-ICMs synthesized at (A) − 14 °C, (B) − 18 °C, (C) − 20 °C and (D) − 22 °C.

Figure 3. The SEM images of MMC-ICMs synthesized at (A) − 14 °C, (B) − 18 °C, (C) − 20 °C and (D) − 22 °C.

Figure 4. The SEM photograph of MMC-ICMs synthesized with different monomer ratios at −14 °C: (A) 1:16, (B) 1:10, (C) 1:8 and (D) 1:4 nHEMA/nMBAAm.

Figure 4. The SEM photograph of MMC-ICMs synthesized with different monomer ratios at −14 °C: (A) 1:16, (B) 1:10, (C) 1:8 and (D) 1:4 nHEMA/nMBAAm.

Table 2. Comparison of the properties of cryogel membranes.

Figure 5. Effect of cross-linker ratio on the MMC release (BPS buffer, 37 °C, n = 3).

Figure 5. Effect of cross-linker ratio on the MMC release (BPS buffer, 37 °C, n = 3).

Figure 6. Effect of loaded drug concentration on the MMC release from MMC-ICM4.

Figure 6. Effect of loaded drug concentration on the MMC release from MMC-ICM4.

Figure 7. Effect of polymerization temperature on MMC delivery from the cryogel membranes.

Figure 7. Effect of polymerization temperature on MMC delivery from the cryogel membranes.

Table 3. Release kinetics data for MMC-ICMs.

Figure 8. The viability of cell lines treated with MMC-ICMs and PHEMA-ICM (50, 75 and 100 μg MMC/mL) after 12 and 24 h.

Figure 8. The viability of cell lines treated with MMC-ICMs and PHEMA-ICM (50, 75 and 100 μg MMC/mL) after 12 and 24 h.

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