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Original Articles

Improved oral bioavailability of magnolol by using a binary mixed micelle system

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Pages 668-674 | Received 12 Dec 2017, Accepted 17 Apr 2018, Published online: 05 Sep 2018

Figures & data

Figure 1. Chemical structure and structural representation of MO-M.

Figure 1. Chemical structure and structural representation of MO-M.

Figure 2. TEM micrographs and image of MO-H (A); TEM micrographs and image of MO-T (B); Scale bar = 100 nm. Size distribution of MO-H (C); Size distribution of MO-T (D).

Figure 2. TEM micrographs and image of MO-H (A); TEM micrographs and image of MO-T (B); Scale bar = 100 nm. Size distribution of MO-H (C); Size distribution of MO-T (D).

Table 1. Characteristics of MO loaded mixed micelles system.

Table 2. Average size and PDI of MO-M diluted from 1 to 250 folds with Milli-Q water.

Figure 3. Cumulative release of MO-M in vitro release study with phosphate buffered saline pH 1.2 (A) and pH 6.8 (B). Date are presented as mean ± SD (n = 3).

Figure 3. Cumulative release of MO-M in vitro release study with phosphate buffered saline pH 1.2 (A) and pH 6.8 (B). Date are presented as mean ± SD (n = 3).

Table 3. Permeability and efflux ratio of MO-H, MO-T and MO in Caco-2 cell model.

Figure 4. The plasma drug concentration–time curve in rats after oral administration of 80 mg/kg of MO-H, MO-T and MO. Date are presented as mean ± SD (n = 6).

Figure 4. The plasma drug concentration–time curve in rats after oral administration of 80 mg/kg of MO-H, MO-T and MO. Date are presented as mean ± SD (n = 6).

Table 4. Pharmacokinetic parameters of MO-H, MO-T and MO.

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