The expression level and diagnostic value of microRNA-22 in HCC patients

Figures & data

Table 1. Relationship between serum miR-22 expression and clinicopathological features of HCC patients.

Characteristics	Cases (n = 108)	miR-22 expression		p Values
		Low (n = 60)	High (n = 48)
Gender
Male	58	32	26	.931
Female	50	28	22
Age (years)
<50	60	35	25	.516
≧50	48	25	23
Tumour size
<5 cm	53	31	22	.547
≧5 cm	55	29	26
Vein invasion
Negative	75	49	26	.002
Positive	33	11	22
Liver cirrhosis
Negative	55	32	23	.576
Positive	53	28	25
TNM stage
I + II	70	45	25	.013
III + IV	38	15	23
Histologic grade
Well	36	18	18	.714
Moderate	36	21	15
Poor	36	21	15
Hepatitis B virus infection
Negative	55	34	21	.245
Positive	53	26	27

Figure 1. Serum miR-22 levels were down-regulated in HCC patients compared to that in healthy controls (p < .05).

Figure 2. The comparison of biochemical parameters in HCC patients based on their expression levels of miR-22, including AFP (α-fetoprotein), ALT (alanine aminotransferase), AST (aspartate aminotransferase) and ALP (alkaline phosphatase). All the mentioned factors exhibited significantly higher level in the serum of HCC patients with low miR-22 expression than in high expression. ***p < .001 represented the significant difference between the compared two groups.

Figure 3. ROC curve for the evaluation of the accuracy of miR-22 to discriminate patients with HCC from healthy controls.