Factors affecting response variables with emphasis on drug release and loading for optimization of liposomes

Figures & data

Figure 1. General structure of Liposomes [2].

Figure 2. General formation and structural capabilities of liposomes [17].

Table 1. Studies involving nucleic acids-loaded liposomes in various clinical stages.

Study No.	Status	Study title	Target Condition	Phase	Study reference
1	Recruiting	A Study of RNA-lipid Particle (RNA-LP) Vaccines	Adult Glioblastoma	Phase I	NCT04573140
2	Recruiting	mRNA liposomal Vaccine in Combination with (Neo-)Adjuvant Chemotherapy (OLIVIA)	Ovarian Cancer	Phase I	NCT04163094
3	Active	EphA2 siRNA in Treating Advanced or Recurrent Solid tumours	Advanced Malignant Solid Neoplasm	Phase I	NCT01591356
4	Completed	Study to determine maximum tolerated dose of LErafAON Linked with Radiotherapy	Neoplasms	Phase I	NCT00024648
5	Completed	Study with Atu027 in Patients with Advanced Solid Cancer	Advanced Solid Tumours	Phase I	NCT00938574
6	Completed	Study of Gene Therapy for Cystic Fibrosis	Cystic Fibrosis	Phase I	NCT00004471
7	Completed	Interleukin Gene or Methotrexate in Treating Patients with Recurrent or Refractory Stage III and IV Head and Neck Cancer	Head and Neck Cancer	Phase II	NCT00006033
8	Completed	Phase I Study of IV DOTAP: CHOL-Fus1 in NSCLC	Lung Cancer	Phase I	NCT00059605
9	Recruiting	BP1001 in Pattern with Venetoclax Plus Decitabine in AML	Acute Myeloid Leukaemia (AML)	Phase II	NCT02781883
10	Completed	BP1001 (L-Grb-2 Antisense Oligonucleotide) in CML, AML, ALL & MDS	CML, AML, ALL & MDS	Phase I	NCT01159028
11	Active	Cancer Vaccine to treat Advanced Melanoma (Lipo-MERIT)	Melanoma	Phase I	NCT02410733
12	Recruiting	Autogene Cevumeran (RO7198457) as a Single Agent and in Sequence with Atezolizumab in Participants with Locally Advanced or Metastatic Tumours	Solid Cancers	Phase I	NCT03289962
15	Completed	Gene Therapy in CF Patients	Cystic Fibrosis	Phase II	NCT016211867

Pande S. Liposomes for drug delivery: review of vesicular composition, factors affecting drug release and drug loading in liposomes. Artif Cells Nanomed Biotechnol. 2023;51(1):428–440. doi: 10.1080/21691401.2023.2247036.

 PubMed Web of Science ®Google Scholar

Eras A, Castillo D, Suárez M, et al. Chemical conjugation in drug delivery systems. Front Chem. 2022;10:889083. doi: 10.3389/fchem.2022.889083.

 PubMed Web of Science ®Google Scholar

Data availability statement

There is no new data related to this submission.