https://orcid.org/0000-0003-0802-1220
Figures & data
Figure 1. A. Potential targets for treatment of SARS-CoV-2 infection at the receptor level affecting downstream immune responses to the virus. B. The introduction of personalized variability to counter resistance to antiviral treatments. Regular, fixed dosing using an antiviral agent with robust and rapid effects is expected to lead to viral clearance, while fixed dosing regimens of moderately effective drugs may lead to drug resistance, viral persistence, an augmented hyperactivation of the immune system, and severe disease. The introduction of an algorithm-based dosing method based on quantified variability patterns derived from disease and host parameters improves the response to antiviral drugs.
