Genetic variants in human BCL2L11 (BIM) are associated with ulcerative forms of Buruli ulcer

Figures & data

Table 1. Genotype distributions and association test results of SNPs in the BCL2L11 gene among BU patients and healthy endemic controls (left) and among BU patients with non-ulcerative and ulcerative forms of the disease (right).

SNP rs#	Genotype	Cases (%)	Controls (%)	OR [95% CI]	t-statistic	p-value	Empirical p-value	Adjusted empirical p-value	Non-ulcerated (%)	Ulcerated (%)	OR [95% CI]	t-statistic	p-value	Empirical p-value	Adjusted empirical p-value
rs1821968	GG	133 (42.9)	131 (42.4)	0.913 [0.719-1.162]	-0.735	0.462	0.502	0.917	29 (36.7)	95 (44.6)	1.264 [0.851-1.878]	1.159	0.246	0.264	0.656
	GA	145 (46.9)	146 (47.7)						41 (51.9)	98 (46.0)
	AA	32 (10.4)	32 (10.5)						9 (11.4)	20 (9.4)
rs17041869	AA	260 (84.1)	257 (83.2)	1.040 [0.707-1.529]	0.197	0.844	0.795	0.999	63 (79.7)	183 (85.9)	1.461 [0.796-2.684]	1.223	0.221	0.206	0.596
	AG	45 (14.6)	49 (16.0)						15 (19.0)	28 (13.1)
	GG	4 (1.3)	3 (1.0)						1 (1.3)	2 (0.9)
rs9308731	AA	233 (75.4)	235 (76.1)	0.898 [0.650-1.239]	-0.656	0.512	0.508	0.925	64 (81.0)	156 (73.2)	0.697 [0.405-1.199]	-1.305	0.192	0.182	0.530
	AG	66 (21.4)	70 (22.9)						13 (16.5)	49 (23.0)
	GG	10 (3.2)	4 (1.3)						2 (2.5)	8 (3.8)
rs13421194	TT	250 (80.9)	241 (78.0)	1.122 [0.786-1.603]	0.635	0.526	0.481	0.935	57 (72.2)	181 (85.0)	2.017 [1.157-3.518]	2.474	0.013	0.016	0.048
	TC	54 (17.5)	65 (21.2)						20 (25.3)	30 (14.1)
	CC	5 (1.6)	3 (1.0)						2 (2.5)	2 (0.9)

Data availability statement

The data that support the findings of this study are available from the corresponding author, A.G.F., upon reasonable request.

Acknowledgements

The authors would like to thank all the participants for their openness and patience to participate in the study.